Seroatlas · Human Serome Atlas

SYCP1

Synaptonemal complex protein 1

Also known as: CT8, HOM-TES-14, SCP1, SYCP1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q15431
Gene: SYCP1
Ensembl: ENSG00000198765
Chromosome: 1
Canonical length: 976 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Nuclear bodies,Cytosol
Quaternary structure: Homotetramer

OverviewNCBI Gene

Enables double-stranded DNA binding activity. Involved in protein homotetramerization. Predicted to be located in synaptonemal complex. Predicted to be active in central element; male germ cell nucleus; and transverse filament. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

976 residues, UniProt reviewed canonical sequence.

>Q15431|SYCP1
     1  MEKQKPFALF VPPRSSSSQV SAVKPQTLGG DSTFFKSFNK CTEDDFEFPF AKTNLSKNGE
    61  NIDSDPALQK VNFLPVLEQV GNSDCHYQEG LKDSDLENSE GLSRVYSKLY KEAEKIKKWK
   121  VSTEAELRQK ESKLQENRKI IEAQRKAIQE LQFGNEKVSL KLEEGIQENK DLIKENNATR
   181  HLCNLLKETC ARSAEKTKKY EYEREETRQV YMDLNNNIEK MITAFEELRV QAENSRLEMH
   241  FKLKEDYEKI QHLEQEYKKE INDKEKQVSL LLIQITEKEN KMKDLTFLLE ESRDKVNQLE
   301  EKTKLQSENL KQSIEKQHHL TKELEDIKVS LQRSVSTQKA LEEDLQIATK TICQLTEEKE
   361  TQMEESNKAR AAHSFVVTEF ETTVCSLEEL LRTEQQRLEK NEDQLKILTM ELQKKSSELE
   421  EMTKLTNNKE VELEELKKVL GEKETLLYEN KQFEKIAEEL KGTEQELIGL LQAREKEVHD
   481  LEIQLTAITT SEQYYSKEVK DLKTELENEK LKNTELTSHC NKLSLENKEL TQETSDMTLE
   541  LKNQQEDINN NKKQEERMLK QIENLQETET QLRNELEYVR EELKQKRDEV KCKLDKSEEN
   601  CNNLRKQVEN KNKYIEELQQ ENKALKKKGT AESKQLNVYE IKVNKLELEL ESAKQKFGEI
   661  TDTYQKEIED KKISEENLLE EVEKAKVIAD EAVKLQKEID KRCQHKIAEM VALMEKHKHQ
   721  YDKIIEERDS ELGLYKSKEQ EQSSLRASLE IELSNLKAEL LSVKKQLEIE REEKEKLKRE
   781  AKENTATLKE KKDKKTQTFL LETPEIYWKL DSKAVPSQTV SRNFTSVDHG ISKDKRDYLW
   841  TSAKNTLSTP LPKAYTVKTP TKPKLQQREN LNIPIEESKK KRKMAFEFDI NSDSSETTDL
   901  LSMVSEEETL KTLYRNNNPP ASHLCVKTPK KAPSSLTTPG STLKFGAIRK MREDRWAVIA
   961  KMDRKKKLKE AEKLFV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SYCP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.56
Highest tissue expression: 38 nTPM

Expression across tissuesHPA

Tissue

testis: 38 nTPM
breast: 0.5 nTPM
adipose tissue: 0.1 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM

Single-cell type

early primary spermatocytes: 1,366 nCPM
late primary spermatocytes: 235 nCPM
early spermatids: 104 nCPM
adipocytes: 55 nCPM
late spermatids: 54 nCPM
undifferentiated spermatogonia: 28 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

midbrain: 0.2 nTPM
amygdala: 0.1 nTPM
cerebellum: 0.1 nTPM
thalamus: 0.1 nTPM
basal ganglia: 0 nTPM
cerebral cortex: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.22
gnomAD pLI: 1
gnomAD missense Z: 1.38
DepMap mean gene effect: -0.09
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Synaptonemal complex protein 1
Synaptonemal complex protein 1 (SCP-1)

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SYCP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SYCP1 as an antibody target. Whether an autoantibody or antibody against SYCP1 could matter depends on whether native SYCP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SYCP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SYCP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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