Seroatlas · Human Serome Atlas

IRAG2

Inositol 1,4,5-triphosphate receptor associated 2

Also known as: IRAG2_HUMAN, JAW1, LRMP

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q12912
Gene: IRAG2
Ensembl: ENSG00000118308
Chromosome: 12
Canonical length: 555 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location: Endoplasmic reticulum,Plasma membrane

OverviewNCBI Gene

The protein encode dby this gene is expressed in a developmentally regulated manner in lymphoid cell lines and tissues. The protein is localized to the cytoplasmic face of the endoplasmic reticulum. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

555 residues, UniProt reviewed canonical sequence.

>Q12912|IRAG2
     1  MESTPFSGVA NQIHTLCERP TYGEVKDGAL DVKRQHKCPG PTSGPSPGTN LSGCIRMNDD
    61  PSMEENGVER VCPESLLQSR EYSSLPLPRH TSSTDGTITS SDPGLEILNM ASCDLDRNSL
   121  CKKEEDTRSA SPTIEAQGTS PAHDNIAFQD STSKDKTILN LEAKEEPETI EEHKKEHASG
   181  DSVVSPLPVT TVKSVNLRQS ENTSANEKEV EAEFLRLSLG FKCDWFTLEK RVKLEERSRD
   241  LAEENLKKEI TNCLKLLESL TPLCEDDNQA QEIIKKLEKS IKFLSQCAAR VASRAEMLGA
   301  INQESRVSKA VEVMIQHVEN LKRMYAKEHA ELEELKQVLL QNERSFNPLE DDDDCQIKKR
   361  SASLNSKPSS LRRVTIASLP RNIGNAGMVA GMENNDRFSR RSSSWRILGS KQSEHRPSLP
   421  RFISTYSWAD AEEEKCELKT KDDSEPSGEE TVERTRKPSL SEKKNNPSKW DVSSVYDTIA
   481  SWATNLKSSI RKANKALWLS IAFIVLFAAL MSFLTGQLFQ KSVDAAPTQQ EDSWTSLEHI
   541  LWPFTRLRHN GPPPV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IRAG2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.63
Highest tissue expression: 167 nTPM

Expression across tissuesHPA

Tissue

tonsil: 167 nTPM
lymph node: 147 nTPM
thymus: 86 nTPM
bone marrow: 49 nTPM
appendix: 43 nTPM
spleen: 32 nTPM

Single-cell type

tuft cells: 2,686 nCPM
neutrophils: 581 nCPM
microglia: 306 nCPM
neutrophil progenitors: 235 nCPM
b-cells: 198 nCPM
nk-cells: 169 nCPM

Immune cell

eosinophil: 176 nTPM
neutrophil: 136 nTPM
basophil: 77 nTPM
memory B-cell: 60 nTPM
NK-cell: 50 nTPM
naive B-cell: 47 nTPM

Brain region

amygdala: 16 nTPM
hippocampal formation: 12 nTPM
pons: 11 nTPM
basal ganglia: 9.7 nTPM
cerebral cortex: 9.7 nTPM
white matter: 8.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.89
gnomAD pLI: 0
DepMap mean gene effect: -0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

microtubule binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of IRAG2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IRAG2 as an antibody target. Whether an autoantibody or antibody against IRAG2 could matter depends on whether native IRAG2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IRAG2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label IRAG2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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