SUN domain
IPR012919
Definition
Sad1/UNC-84 (SUN)-domain proteins are inner nuclear membrane (INM) proteins that are part of bridging complexes linking cytoskeletal elements with the nucleoskeleton. Originally identified based on an ~150-amino acid region of homology between the C terminus of the Schizosaccharomyces pombe Sad1 protein and the Caenorhabditis elegans UNC-84 protein, SUN proteins are present in the proteomes of most eucaryotes. In addition to the SUN domain, these proteins contain a transmembrane sequence and at least one coiled-coil domain and localise to the inner nuclear envelope. SUN proteins are anchored in the inner nuclear envelope by their transmembrane segment and oriented in the membrane such that the C-terminal SUN domain is located in the space between the inner and outer nuclear membrane. Here, the SUN domain can interact with the C- terminal tail of an outer nuclear envelope protein that binds to the cytoskeleton, including the centrosome [[cite:PMID:15611647], [cite:PMID:16923827], [cite:PMID:19807882]]. Some proteins known to contain a SUN domain are listed below: Fission yeast spindle pole body-associated protein Sad1. Yeast spindle pole body assembly component MPS3, essential for nuclear division and fusion. Yeast uncharacterised protein SLP1. Caenorhabditis nuclear migration and anchoring protein UNC-84. Caenorhabditis SUN domain-containing protein 1 (sun-1), involved in centrosome attachment to the nucleus. Mammalian sperm-associated antigen 4 protein (SPAG4), may assist the organisation and assembly of outer dense fibres (ODFs), a specific structure of the sperm tail. Mammalian sperm-associated antigen 4-like protein (SPAG4L). Mammalian SUN1. Mammalian SUN2. Mammalian SUN3. Klaroid protein from Drosophila melanogaster PMID:18820457.
7 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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