Seroatlas · Human Serome Atlas

KASH5

Protein KASH5

Also known as: CCDC155, FLJ32658, KASH5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8N6L0
Gene
KASH5
Ensembl
ENSG00000161609
Chromosome
19
Canonical length
562 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

Predicted to enable dynein complex binding activity. Predicted to be involved in several processes, including cytoskeleton organization; homologous chromosome segregation; and spindle localization. Predicted to act upstream of or within several processes, including double-strand break repair via homologous recombination; meiotic telomere clustering; and spermatogenesis. Predicted to be located in chromosome; membrane; and nuclear envelope. Predicted to be part of meiotic nuclear membrane microtubule tethering complex. Predicted to be active in chromosome; meiotic spindle pole; and nuclear outer membrane. Implicated in primary ovarian insufficiency and spermatogenic failure 88. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

562 residues, UniProt reviewed canonical sequence.

>Q8N6L0|KASH5
     1  MDLPEGPVGG PTAEMYLRER PEEARLGMPV SLEEQILNST FEACDPQRTG TVAVAQVLAY
    61  LEAVTGQGPQ DARLQTLANS LDPNGEGPKA TVDLDTFLVV MRDWIAACQL HGGLELEEET
   121  AFQGALTSRQ LPSGCPEAEE PANLESFGGE DPRPELQATA DLLSSLEDLE LSNRRLVGEN
   181  AKLQRSMETA EEGSARLGEE ILALRKQLHS TQQALQFAKA MDEELEDLKT LARSLEEQNR
   241  SLLAQARQAE KEQQHLVAEM ETLQEENGKL LAERDGVKKR SQELAMEKDT LKRQLFECEH
   301  LICQRDTILS ERTRDVESLA QTLEEYRVTT QELRLEISRL EEQLSQTYEG PDELPEGAQL
   361  RRVGWTELLP PSLGLEIEAI RQKQEVATAD LSNPLCGVWQ WEEVIHETSE ETEFPSEAPA
   421  GGQRNFQGEP AHPEEGRKEP SMWLTRREEE EDAESQVTAD LPVPLGAPRP GDIPENPPER
   481  PARRELQQAL VPVMKKLVPV RRRAWGQLCL PPQRLRVTRH PLIPAPVLGL LLLLLLSVLL
   541  LGPSPPPTWP HLQLCYLQPP PV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KASH5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.57
Highest tissue expression
52 nTPM

Expression across tissuesHPA

Tissue

  • testis: 52 nTPM
  • cerebellum: 12 nTPM
  • retina: 6.9 nTPM
  • pancreas: 1.8 nTPM
  • choroid plexus: 0.4 nTPM
  • lung: 0.1 nTPM

Single-cell type

  • early primary spermatocytes: 154 nCPM
  • early spermatids: 84 nCPM
  • late primary spermatocytes: 80 nCPM
  • retinal bipolar cells: 57 nCPM
  • late spermatids: 31 nCPM
  • differentiating spermatogonia: 31 nCPM

Immune cell

  • naive B-cell: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • cerebellum: 8.6 nTPM
  • pons: 0.8 nTPM
  • cerebral cortex: 0.3 nTPM
  • hypothalamus: 0.3 nTPM
  • white matter: 0.2 nTPM
  • basal ganglia: 0.1 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about KASH5.

Disease | AllUniProt

Conditions KASH5 is implicated in, by any mechanism.

Disease | GeneticClinVar

7 pathogenic / likely-pathogenic of 111 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.79
gnomAD pLI
0
DepMap mean gene effect
-0.02
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • EF-hand domain pair
  • KASH5-like coiled-coil domain
  • Protein KASH5
  • Protein KASH5, EF-hand-like domain
  • EF-hand domain
  • Coiled-coil region of CCDC155 or KASH

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KASH5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KASH5 as an antibody target. Whether an autoantibody or antibody against KASH5 could matter depends on whether native KASH5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KASH5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KASH5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/KASH5. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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