STEAP family metalloreductases

Definition

The STEAP family proteins are integral membrane metalloreductases that function as NADPH-dependent ferric-chelate reductases. They facilitate the reduction of Fe(3+) to Fe(2+) across cellular membranes, using NADPH to transfer electrons through FAD and heme groups to the iron chelate. Some family members also reduce Cu(2+) to Cu(1+). These proteins play roles in iron uptake, particularly in erythroid cells, and are involved in systemic metabolic homeostasis, linking inflammatory responses with metabolic processes. They may influence cell cycle progression and apoptosis, and are implicated in conditions such as obesity, insulin resistance, and inflammatory arthritis. Certain STEAP proteins, despite belonging to the family, lack the necessary binding sites for NADPH and do not function as metalloreductases on their own.

5 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (5 proteins: gene, accession, name)

• STEAP1
• STEAP1B
• STEAP2
• STEAP3
• STEAP4