Seroatlas · Human Serome Atlas

SEC11C

Signal peptidase complex catalytic subunit SEC11C

Also known as: SC11C_HUMAN, SEC11L3, SPC21, SPCS4C

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BY50
Gene: SEC11C
Ensembl: ENSG00000166562
Chromosome: 18
Canonical length: 192 aa
Protein class: Enzymes, Metabolic proteins, Predicted membrane proteins
Subcellular location: Nuclear membrane,Golgi apparatus

OverviewNCBI Gene

Enables serine-type endopeptidase activity. Involved in signal peptide processing. Located in endoplasmic reticulum membrane. Part of signal peptidase complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

192 residues, UniProt reviewed canonical sequence.

>Q9BY50|SEC11C
     1  MVRAGAVGAH LPASGLDIFG DLKKMNKRQL YYQVLNFAMI VSSALMIWKG LIVLTGSESP
    61  IVVVLSGSME PAFHRGDLLF LTNFREDPIR AGEIVVFKVE GRDIPIVHRV IKVHEKDNGD
   121  IKFLTKGDNN EVDDRGLYKE GQNWLEKKDV VGRARGFLPY VGMVTIIMND YPKFKYALLA
   181  VMGAYVLLKR ES

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SEC11C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 374 nTPM

Expression across tissuesHPA

Tissue

salivary gland: 374 nTPM
pancreas: 353 nTPM
epididymis: 268 nTPM
spinal cord: 241 nTPM
pituitary gland: 218 nTPM
prostate: 212 nTPM

Single-cell type

plasma cells: 1,836 nCPM
epididymal principal cells: 989 nCPM
respiratory ionocytes: 808 nCPM
prostatic glandular cells: 792 nCPM
salivary acinar cells: 569 nCPM
pancreatic islet cells: 472 nCPM

Immune cell

plasmacytoid DC: 300 nTPM
T-reg: 224 nTPM
total PBMC: 222 nTPM
memory B-cell: 199 nTPM
MAIT T-cell: 188 nTPM
memory CD4 T-cell: 151 nTPM

Brain region

hypothalamus: 145 nTPM
medulla oblongata: 126 nTPM
white matter: 117 nTPM
midbrain: 110 nTPM
spinal cord: 95 nTPM
cerebellum: 93 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.55
gnomAD pLI: 0.72
gnomAD missense Z: 2
DepMap mean gene effect: 0.13
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

signal peptide processing

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SEC11C in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SEC11C as an antibody target. Whether an autoantibody or antibody against SEC11C could matter depends on whether native SEC11C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SEC11C is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SEC11C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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