Seroatlas · Human Serome Atlas

SPCS1

Signal peptidase complex subunit 1

Also known as: HSPC033, SPC1, SPC12, SPCS1_HUMAN, YJR010C-A

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y6A9
Gene: SPCS1
Ensembl: ENSG00000114902
Chromosome: 3
Canonical length: 169 aa
Protein class: Metabolic proteins, Predicted membrane proteins
Subcellular location: Golgi apparatus,Vesicles

OverviewNCBI Gene

Predicted to enable ribosome binding activity. Involved in signal peptide processing; viral protein processing; and virion assembly. Located in endoplasmic reticulum membrane. Part of signal peptidase complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

169 residues, UniProt reviewed canonical sequence.

>Q9Y6A9|SPCS1
     1  MARGGDTGCT GPSETSASGA AAIALPGLEG PATDAQCQTL PLTVLKSRSP SPRSLPPALS
    61  CPPPQPAMLE HLSSLPTQMD YKGQKLAEQM FQGIILFSAI VGFIYGYVAE QFGWTVYIVM
   121  AGFAFSCLLT LPPWPIYRRH PLKWLPVQES STDDKKPGER KIKRHAKNN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SPCS1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 2
Mean surface accessibility (rSASA): 0.61
Highest tissue expression: 178 nTPM

Expression across tissuesHPA

Tissue

pancreas: 178 nTPM
choroid plexus: 133 nTPM
liver: 132 nTPM
testis: 120 nTPM
kidney: 118 nTPM
salivary gland: 117 nTPM

Single-cell type

late spermatids: 2,010 nCPM
plasma cells: 1,112 nCPM
esophageal apical cells: 894 nCPM
late primary spermatocytes: 861 nCPM
parietal cells: 808 nCPM
pdcs: 685 nCPM

Immune cell

plasmacytoid DC: 622 nTPM
basophil: 294 nTPM
eosinophil: 259 nTPM
total PBMC: 254 nTPM
memory B-cell: 203 nTPM
T-reg: 178 nTPM

Brain region

choroid plexus: 83 nTPM
white matter: 74 nTPM
hypothalamus: 73 nTPM
medulla oblongata: 69 nTPM
spinal cord: 69 nTPM
thalamus: 68 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.13
gnomAD pLI: 0.01
gnomAD missense Z: 0.46
DepMap mean gene effect: -0.19
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

Signal peptidase complex subunit 1
Microsomal signal peptidase 12 kDa subunit (SPC12)

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SPCS1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SPCS1 as an antibody target. Whether an autoantibody or antibody against SPCS1 could matter depends on whether native SPCS1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SPCS1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SPCS1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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