Seroatlas · Human Serome Atlas

TENM1

Teneurin-1

Also known as: ODZ1, ODZ3, TEN-M1, TEN1, TEN1_HUMAN, TNM

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UKZ4
Gene: TENM1
Ensembl: ENSG00000009694
Chromosome: X
Canonical length: 2725 aa
Protein class: Predicted membrane proteins, Transporters
Subcellular location: Nucleoplasm,Plasma membrane
Quaternary structure: Homodimer

OverviewNCBI Gene

The protein encoded by this gene belongs to the tenascin family and teneurin subfamily. It is expressed in the neurons and may function as a cellular signal transducer. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

Canonical amino-acid sequenceUniProt

2725 residues, UniProt reviewed canonical sequence.

>Q9UKZ4|TENM1
     1  MEQTDCKPYQ PLPKVKHEMD LAYTSSSDES EDGRKPRQSY NSRETLHEYN QELRMNYNSQ
    61  SRKRKEVEKS TQEMEFCETS HTLCSGYQTD MHSVSRHGYQ LEMGSDVDTE TEGAASPDHA
   121  LRMWIRGMKS EHSSCLSSRA NSALSLTDTD HERKSDGENG FKFSPVCCDM EAQAGSTQDV
   181  QSSPHNQFTF RPLPPPPPPP HACTCARKPP PAADSLQRRS MTTRSQPSPA APAPPTSTQD
   241  SVHLHNSWVL NSNIPLETRH FLFKHGSGSS AIFSAASQNY PLTSNTVYSP PPRPLPRSTF
   301  SRPAFTFNKP YRCCNWKCTA LSATAITVTL ALLLAYVIAV HLFGLTWQLQ PVEGELYANG
   361  VSKGNRGTES MDTTYSPIGG KVSDKSEKKV FQKGRAIDTG EVDIGAQVMQ TIPPGLFWRF
   421  QITIHHPIYL KFNISLAKDS LLGIYGRRNI PPTHTQFDFV KLMDGKQLVK QDSKGSDDTQ
   481  HSPRNLILTS LQETGFIEYM DQGPWYLAFY NDGKKMEQVF VLTTAIEIMD DCSTNCNGNG
   541  ECISGHCHCF PGFLGPDCAR DSCPVLCGGN GEYEKGHCVC RHGWKGPECD VPEEQCIDPT
   601  CFGHGTCIMG VCICVPGYKG EICEEEDCLD PMCSNHGICV KGECHCSTGW GGVNCETPLP
   661  VCQEQCSGHG TFLLDAGVCS CDPKWTGSDC STELCTMECG SHGVCSRGIC QCEEGWVGPT
   721  CEERSCHSHC TEHGQCKDGK CECSPGWEGD HCTIAHYLDA VRDGCPGLCF GNGRCTLDQN
   781  GWHCVCQVGW SGTGCNVVME MLCGDNLDND GDGLTDCVDP DCCQQSNCYI SPLCQGSPDP
   841  LDLIQQSQTL FSQHTSRLFY DRIKFLIGKD STHVIPPEVS FDSRRACVIR GQVVAIDGTP
   901  LVGVNVSFLH HSDYGFTISR QDGSFDLVAI GGISVILIFD RSPFLPEKRT LWLPWNQFIV
   961  VEKVTMQRVV SDPPSCDISN FISPNPIVLP SPLTSFGGSC PERGTIVPEL QVVQEEIPIP
  1021  SSFVRLSYLS SRTPGYKTLL RILLTHSTIP VGMIKVHLTV AVEGRLTQKW FPAAINLVYT
  1081  FAWNKTDIYG QKVWGLAEAL VSVGYEYETC PDFILWEQRT VVLQGFEMDA SNLGGWSLNK
  1141  HHILNPQSGI IHKGNGENMF ISQQPPVIST IMGNGHQRSV ACTNCNGPAH NNKLFAPVAL
  1201  ASGPDGSVYV GDFNFVRRIF PSGNSVSILE LSTSPAHKYY LAMDPVSESL YLSDTNTRKV
  1261  YKLKSLVETK DLSKNFEVVA GTGDQCLPFD QSHCGDGGRA SEASLNSPRG ITVDRHGFIY
  1321  FVDGTMIRKI DENAVITTVI GSNGLTSTQP LSCDSGMDIT QVRLEWPTDL AVNPMDNSLY
  1381  VLDNNIVLQI SENRRVRIIA GRPIHCQVPG IDHFLVSKVA IHSTLESARA ISVSHSGLLF
  1441  IAETDERKVN RIQQVTTNGE IYIIAGAPTD CDCKIDPNCD CFSGDGGYAK DAKMKAPSSL
  1501  AVSPDGTLYV ADLGNVRIRT ISRNQAHLND MNIYEIASPA DQELYQFTVN GTHLHTLNLI
  1561  TRDYVYNFTY NSEGDLGAIT SSNGNSVHIR RDAGGMPLWL VVPGGQVYWL TISSNGVLKR
  1621  VSAQGYNLAL MTYPGNTGLL ATKSNENGWT TVYEYDPEGH LTNATFPTGE VSSFHSDLEK
  1681  LTKVELDTSN RENVLMSTNL TATSTIYILK QENTQSTYRV NPDGSLRVTF ASGMEIGLSS
  1741  EPHILAGAVN PTLGKCNISL PGEHNANLIE WRQRKEQNKG NVSAFERRLR AHNRNLLSID
  1801  FDHITRTGKI YDDHRKFTLR ILYDQTGRPI LWSPVSRYNE VNITYSPSGL VTFIQRGTWN
  1861  EKMEYDQSGK IISRTWADGK IWSYTYLEKS VMLLLHSQRR YIFEYDQPDC LLSVTMPSMV
  1921  RHSLQTMLSV GYYRNIYTPP DSSTSFIQDY SRDGRLLQTL HLGTGRRVLY KYTKQARLSE
  1981  VLYDTTQVTL TYEESSGVIK TIHLMHDGFI CTIRYRQTGP LIGRQIFRFS EEGLVNARFD
  2041  YSYNNFRVTS MQAVINETPL PIDLYRYVDV SGRTEQFGKF SVINYDLNQV ITTTVMKHTK
  2101  IFSANGQVIE VQYEILKAIA YWMTIQYDNV GRMVICDIRV GVDANITRYF YEYDADGQLQ
  2161  TVSVNDKTQW RYSYDLNGNI NLLSHGKSAR LTPLRYDLRD RITRLGEIQY KMDEDGFLRQ
  2221  RGNDIFEYNS NGLLQKAYNK ASGWTVQYYY DGLGRRVASK SSLGQHLQFF YADLTNPIRV
  2281  THLYNHTSSE ITSLYYDLQG HLIAMELSSG EEYYVACDNT GTPLAVFSSR GQVIKEILYT
  2341  PYGDIYHDTY PDFQVIIGFH GGLYDFLTKL VHLGQRDYDV VAGRWTTPNH HIWKQLNLLP
  2401  KPFNLYSFEN NYPVGKIQDV AKYTTDIRSW LELFGFQLHN VLPGFPKPEL ENLELTYELL
  2461  RLQTKTQEWD PGKTILGIQC ELQKQLRNFI SLDQLPMTPR YNDGRCLEGG KQPRFAAVPS
  2521  VFGKGIKFAI KDGIVTADII GVANEDSRRL AAILNNAHYL ENLHFTIEGR DTHYFIKLGS
  2581  LEEDLVLIGN TGGRRILENG VNVTVSQMTS VLNGRTRRFA DIQLQHGALC FNIRYGTTVE
  2641  EEKNHVLEIA RQRAVAQAWT KEQRRLQEGE EGIRAWTEGE KQQLLSTGRV QGYDGYFVLS
  2701  VEQYLELSDS ANNIHFMRQS EIGRR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TENM1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0
Highest tissue expression: 18 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 18 nTPM
thymus: 7.5 nTPM
liver: 7.4 nTPM
pituitary gland: 4.4 nTPM
prostate: 4.4 nTPM
hypothalamus: 2.9 nTPM

Single-cell type

prostatic glandular cells: 1,397 nCPM
neutrophils: 1,060 nCPM
lactotrophs: 600 nCPM
retinal amacrine cells: 438 nCPM
corticotrophs: 433 nCPM
adrenal medulla cells: 330 nCPM

Immune cell

neutrophil: 0.5 nTPM
naive CD4 T-cell: 0.3 nTPM
memory CD8 T-cell: 0.2 nTPM
naive CD8 T-cell: 0.2 nTPM
gdT-cell: 0.1 nTPM
MAIT T-cell: 0.1 nTPM

Brain region

cerebellum: 53 nTPM
hypothalamus: 17 nTPM
basal ganglia: 15 nTPM
cerebral cortex: 14 nTPM
amygdala: 14 nTPM
thalamus: 14 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TENM1.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 736 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Moyamoya angiopathy

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.19
gnomAD pLI: 1
gnomAD missense Z: 3.43
DepMap mean gene effect: 0.08
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TENM1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TENM1 as an antibody target. Whether an autoantibody or antibody against TENM1 could matter depends on whether native TENM1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TENM1 is annotated at the cell surface, where native TENM1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TENM1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...