Seroatlas · Human Serome Atlas

INPPL1

Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2

Also known as: SHIP2, SHIP2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O15357
Gene: INPPL1
Ensembl: ENSG00000165458
Chromosome: 11
Canonical length: 1258 aa
Protein class: Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins
Subcellular location: Golgi apparatus,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is an SH2-containing 5'-inositol phosphatase that is involved in the regulation of insulin function. The encoded protein also plays a role in the regulation of epidermal growth factor receptor turnover and actin remodelling. Additionally, this gene supports metastatic growth in breast cancer and is a valuable biomarker for breast cancer. [provided by RefSeq, Jan 2009]

Canonical amino-acid sequenceUniProt

1258 residues, UniProt reviewed canonical sequence.

>O15357|INPPL1
     1  MASACGAPGP GGALGSQAPS WYHRDLSRAA AEELLARAGR DGSFLVRDSE SVAGAFALCV
    61  LYQKHVHTYR ILPDGEDFLA VQTSQGVPVR RFQTLGELIG LYAQPNQGLV CALLLPVEGE
   121  REPDPPDDRD ASDGEDEKPP LPPRSGSTSI SAPTGPSSPL PAPETPTAPA AESAPNGLST
   181  VSHDYLKGSY GLDLEAVRGG ASHLPHLTRT LATSCRRLHS EVDKVLSGLE ILSKVFDQQS
   241  SPMVTRLLQQ QNLPQTGEQE LESLVLKLSV LKDFLSGIQK KALKALQDMS STAPPAPQPS
   301  TRKAKTIPVQ AFEVKLDVTL GDLTKIGKSQ KFTLSVDVEG GRLVLLRRQR DSQEDWTTFT
   361  HDRIRQLIKS QRVQNKLGVV FEKEKDRTQR KDFIFVSARK REAFCQLLQL MKNKHSKQDE
   421  PDMISVFIGT WNMGSVPPPK NVTSWFTSKG LGKTLDEVTV TIPHDIYVFG TQENSVGDRE
   481  WLDLLRGGLK ELTDLDYRPI AMQSLWNIKV AVLVKPEHEN RISHVSTSSV KTGIANTLGN
   541  KGAVGVSFMF NGTSFGFVNC HLTSGNEKTA RRNQNYLDIL RLLSLGDRQL NAFDISLRFT
   601  HLFWFGDLNY RLDMDIQEIL NYISRKEFEP LLRVDQLNLE REKHKVFLRF SEEEISFPPT
   661  YRYERGSRDT YAWHKQKPTG VRTNVPSWCD RILWKSYPET HIICNSYGCT DDIVTSDHSP
   721  VFGTFEVGVT SQFISKKGLS KTSDQAYIEF ESIEAIVKTA SRTKFFIEFY STCLEEYKKS
   781  FENDAQSSDN INFLKVQWSS RQLPTLKPIL ADIEYLQDQH LLLTVKSMDG YESYGECVVA
   841  LKSMIGSTAQ QFLTFLSHRG EETGNIRGSM KVRVPTERLG TRERLYEWIS IDKDEAGAKS
   901  KAPSVSRGSQ EPRSGSRKPA FTEASCPLSR LFEEPEKPPP TGRPPAPPRA APREEPLTPR
   961  LKPEGAPEPE GVAAPPPKNS FNNPAYYVLE GVPHQLLPPE PPSPARAPVP SATKNKVAIT
  1021  VPAPQLGHHR HPRVGEGSSS DEESGGTLPP PDFPPPPLPD SAIFLPPSLD PLPGPVVRGR
  1081  GGAEARGPPP PKAHPRPPLP PGPSPASTFL GEVASGDDRS CSVLQMAKTL SEVDYAPAGP
  1141  ARSALLPGPL ELQPPRGLPS DYGRPLSFPP PRIRESIQED LAEEAPCLQG GRASGLGEAG
  1201  MSAWLRAIGL ERYEEGLVHN GWDDLEFLSD ITEEDLEEAG VQDPAHKRLL LDTLQLSK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against INPPL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.41
Highest tissue expression: 109 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 109 nTPM
colon: 85 nTPM
heart muscle: 70 nTPM
ovary: 66 nTPM
prostate: 66 nTPM
thyroid gland: 65 nTPM

Single-cell type

proximal tubule cells: 59 nCPM
astrocytes: 58 nCPM
megakaryocytes: 56 nCPM
breast lactating cells: 47 nCPM
salivary ionocytes: 46 nCPM
microglia: 45 nCPM

Immune cell

non-classical monocyte: 3.7 nTPM
classical monocyte: 3.5 nTPM
eosinophil: 3.3 nTPM
basophil: 2.5 nTPM
myeloid DC: 2.4 nTPM
neutrophil: 2.4 nTPM

Brain region

medulla oblongata: 109 nTPM
thalamus: 99 nTPM
choroid plexus: 95 nTPM
pons: 94 nTPM
spinal cord: 92 nTPM
midbrain: 89 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about INPPL1.

Disease | AllUniProt

Conditions INPPL1 is implicated in, by any mechanism.

Opsismodysplasia (OPSMD) MIM:258480

Disease | GeneticClinVar

43 pathogenic / likely-pathogenic of 763 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Opsismodysplasia
Thyroid cancer, nonmedullary, 1

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.42
gnomAD pLI: 0
gnomAD missense Z: 1.6
DepMap mean gene effect: 0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of INPPL1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads INPPL1 as an antibody target. Whether an autoantibody or antibody against INPPL1 could matter depends on whether native INPPL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

INPPL1 is annotated at the cell surface, where native INPPL1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label INPPL1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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