Seroatlas · Human Serome Atlas

FRS3

Fibroblast growth factor receptor substrate 3

Also known as: FRS2B, FRS2beta, FRS3_HUMAN, SNT-2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O43559
Gene
FRS3
Ensembl
ENSG00000137218
Chromosome
6
Canonical length
492 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a substrate for the fibroblast growth factor receptor. The encoded protein is found in the peripheral plasma membrane and links fibroblast growth factor receptor stimulation to activators of Ras. The encoded protein down-regulates extracellular regulated kinase 2 through direct binding. [provided by RefSeq, Jul 2013]

Canonical amino-acid sequenceUniProt

492 residues, UniProt reviewed canonical sequence.

>O43559|FRS3
     1  MGSCCSCLNR DSVPDNHPTK FKVTNVDDEG VELGSGVMEL TQSELVLHLH RREAVRWPYL
    61  CLRRYGYDSN LFSFESGRRC QTGQGIFAFK CSRAEEIFNL LQDLMQCNSI NVMEEPVIIT
   121  RNSHPAELDL PRAPQPPNAL GYTVSSFSNG CPGEGPRFSA PRRLSTSSLR HPSLGEESTH
   181  ALIAPDEQSH TYVNTPASED DHRRGRHCLQ PLPEGQAPFL PQARGPDQRD PQVFLQPGQV
   241  KFVLGPTPAR RHMVKCQGLC PSLHDPPHHN NNNEAPSECP AQPKCTYENV TGGLWRGAGW
   301  RLSPEEPGWN GLAHRRAALL HYENLPPLPP VWESQAQQLG GEAGDDGDSR DGLTPSSNGF
   361  PDGEEDETPL QKPTSTRAAI RSHGSFPVPL TRRRGSPRVF NFDFRRPGPE PPRQLNYIQV
   421  ELKGWGGDRP KGPQNPSSPQ APMPTTHPAR SSDSYAVIDL KKTVAMSNLQ RALPRDDGTA
   481  RKTRHNSTDL PL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FRS3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.61
Highest tissue expression
28 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 28 nTPM
  • cerebral cortex: 24 nTPM
  • hypothalamus: 21 nTPM
  • hippocampal formation: 18 nTPM
  • amygdala: 17 nTPM
  • testis: 17 nTPM

Single-cell type

  • epicardial cells: 116 nCPM
  • cardiomyocytes: 31 nCPM
  • adrenal medulla cells: 21 nCPM
  • vascular endothelial cells: 20 nCPM
  • retinal ganglion cells: 19 nCPM
  • early primary spermatocytes: 15 nCPM

Immune cell

  • eosinophil: 0.4 nTPM
  • classical monocyte: 0.3 nTPM
  • NK-cell: 0.3 nTPM
  • plasmacytoid DC: 0.3 nTPM
  • memory CD4 T-cell: 0.2 nTPM
  • myeloid DC: 0.2 nTPM

Brain region

  • cerebral cortex: 43 nTPM
  • white matter: 33 nTPM
  • pons: 30 nTPM
  • basal ganglia: 27 nTPM
  • amygdala: 26 nTPM
  • medulla oblongata: 26 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.46
gnomAD pLI
0.55
gnomAD missense Z
0.92
DepMap mean gene effect
-0.17
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FRS3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FRS3 as an antibody target. Whether an autoantibody or antibody against FRS3 could matter depends on whether native FRS3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FRS3 is annotated at the cell surface, where native FRS3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label FRS3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FRS3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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