SLC7A5
Large neutral amino acids transporter small subunit 1
Also known as: CD98, D16S469E, E16, LAT1, LAT1_HUMAN, MPE16
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q01650
- Gene
- SLC7A5
- Ensembl
- ENSG00000103257
- Chromosome
- 16
- Canonical length
- 507 aa
- Protein class
- Metabolic proteins, Predicted membrane proteins, Transporters
- Subcellular location
- Vesicles,Plasma membrane,Cytosol
OverviewNCBI Gene
Enables L-amino acid transmembrane transporter activity and secondary active transmembrane transporter activity. Involved in carboxylic acid transport; thyroid hormone transport; and xenobiotic transport. Located in several cellular components, including apical plasma membrane; cytosol; and microvillus membrane. Part of amino acid transport complex. Implicated in cholangiocarcinoma; colon cancer; hepatocellular carcinoma; and lung squamous cell carcinoma. Biomarker of esophagitis; gastrointestinal system cancer (multiple); malignant astrocytoma (multiple); and respiratory system cancer (multiple). [provided by Alliance of Genome Resources, Apr 2025]
Canonical amino-acid sequenceUniProt
507 residues, UniProt reviewed canonical sequence.
>Q01650|SLC7A5
1 MAGAGPKRRA LAAPAAEEKE EAREKMLAAK SADGSAPAGE GEGVTLQRNI TLLNGVAIIV
61 GTIIGSGIFV TPTGVLKEAG SPGLALVVWA ACGVFSIVGA LCYAELGTTI SKSGGDYAYM
121 LEVYGSLPAF LKLWIELLII RPSSQYIVAL VFATYLLKPL FPTCPVPEEA AKLVACLCVL
181 LLTAVNCYSV KAATRVQDAF AAAKLLALAL IILLGFVQIG KGDVSNLDPN FSFEGTKLDV
241 GNIVLALYSG LFAYGGWNYL NFVTEEMINP YRNLPLAIII SLPIVTLVYV LTNLAYFTTL
301 STEQMLSSEA VAVDFGNYHL GVMSWIIPVF VGLSCFGSVN GSLFTSSRLF FVGSREGHLP
361 SILSMIHPQL LTPVPSLVFT CVMTLLYAFS KDIFSVINFF SFFNWLCVAL AIIGMIWLRH
421 RKPELERPIK VNLALPVFFI LACLFLIAVS FWKTPVECGI GFTIILSGLP VYFFGVWWKN
481 KPKWLLQGIF STTVLCQKLM QVVPQETLocalizationUniProt · AlphaFold · HPA
Whether an antibody against SLC7A5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 12
- Mean surface accessibility (rSASA)
- 0.27
- Highest tissue expression
- 104 nTPM
Expression across tissuesHPA
Tissue
- bone marrow: 104 nTPM
- esophagus: 96 nTPM
- cerebral cortex: 66 nTPM
- testis: 64 nTPM
- midbrain: 54 nTPM
- hypothalamus: 52 nTPM
Single-cell type
- pdcs: 415 nCPM
- retinal pigment epithelial cells: 401 nCPM
- plasma cells: 292 nCPM
- neutrophils: 267 nCPM
- syncytiotrophoblasts: 203 nCPM
- basal keratinocytes: 201 nCPM
Immune cell
- plasmacytoid DC: 17 nTPM
- T-reg: 1.6 nTPM
- MAIT T-cell: 1.3 nTPM
- basophil: 1 nTPM
- gdT-cell: 1 nTPM
- memory CD8 T-cell: 0.9 nTPM
Brain region
- amygdala: 166 nTPM
- thalamus: 158 nTPM
- medulla oblongata: 144 nTPM
- pons: 129 nTPM
- midbrain: 129 nTPM
- cerebral cortex: 125 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.51
- gnomAD pLI
- 0.24
- gnomAD missense Z
- 1.65
- DepMap mean gene effect
- -0.23
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- alanine transport
- amino acid import across plasma membrane
- amino acid transmembrane transport
- cellular response to glucose starvation
- cellular response to L-arginine
- cellular response to lipopolysaccharide
- isoleucine transport
- L-histidine transport
- L-leucine import across plasma membrane
- L-leucine transport
- L-tryptophan transmembrane transport
- liver regeneration
- methionine transport
- negative regulation of autophagy
- negative regulation of gene expression
- negative regulation of vascular associated smooth muscle cell apoptotic process
- neutral amino acid transport
- phenylalanine transport
- positive regulation of cytokine production involved in immune response
- positive regulation of glial cell proliferation
- positive regulation of interleukin-17 production
- positive regulation of interleukin-4 production
- positive regulation of type II interferon production
- proline transport
- response to hyperoxia
- response to muscle activity
- thyroid hormone transport
- transport across blood-brain barrier
- tryptophan transport
- tyrosine transport
- valine transport
- xenobiotic transport
- positive regulation of L-leucine import across plasma membrane
Molecular functions
- amino acid transmembrane transporter activity
- antiporter activity
- aromatic amino acid transmembrane transporter activity
- L-amino acid transmembrane transporter activity
- L-leucine transmembrane transporter activity
- L-tryptophan transmembrane transporter activity
- neutral L-amino acid transmembrane transporter activity
- peptide antigen binding
- thyroid hormone transmembrane transporter activity
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of SLC7A5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads SLC7A5 as an antibody target. Whether an autoantibody or antibody against SLC7A5 could matter depends on whether native SLC7A5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
SLC7A5 is annotated at the cell surface, where native SLC7A5 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label SLC7A5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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