Seroatlas · Human Serome Atlas

TMEM163

Transmembrane protein 163

Also known as: DKFZP566N034, SV31, TM163_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8TC26
Gene
TMEM163
Ensembl
ENSG00000152128
Chromosome
2
Canonical length
289 aa
Protein class
Predicted membrane proteins, Transporters
Quaternary structure
Homodimer

OverviewNCBI Gene

Predicted to enable zinc ion binding activity. Involved in myelination and zinc export across plasma membrane. Predicted to be located in early endosome membrane. Predicted to be active in plasma membrane and synaptic vesicle membrane. Implicated in hypomyelinating leukodystrophy 25. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

289 residues, UniProt reviewed canonical sequence.

>Q8TC26|TMEM163
     1  MEPAAGIQRR SSQGPTVPPP PRGHAPPAAA PGPAPLSSPV REPPQLEEER QVRISESGQF
    61  SDGLEDRGLL ESSTRLKPHE AQNYRKKALW VSWFSIIVTL ALAVAAFTVS VMRYSASAFG
   121  FAFDAILDVL SSAIVLWRYS NAAAVHSAHR EYIACVILGV IFLLSSICIV VKAIHDLSTR
   181  LLPEVDDFLF SVSILSGILC SILAVLKFML GKVLTSRALI TDGFNSLVGG VMGFSILLSA
   241  EVFKHDSAVW YLDGSIGVLI GLTIFAYGVK LLIDMVPRVR QTRHYEMFE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM163 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
6
Mean surface accessibility (rSASA)
0.37
Highest tissue expression
44 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 44 nTPM
  • pancreas: 26 nTPM
  • spinal cord: 21 nTPM
  • hypothalamus: 17 nTPM
  • tonsil: 15 nTPM
  • cerebral cortex: 14 nTPM

Single-cell type

  • pancreatic acinar cells: 1,089 nCPM
  • alveolar cells type 2: 950 nCPM
  • retinal ganglion cells: 537 nCPM
  • gonadotrophs: 536 nCPM
  • oocytes: 364 nCPM
  • foveolar cells: 353 nCPM

Immune cell

  • T-reg: 0.7 nTPM
  • memory CD8 T-cell: 0.6 nTPM
  • NK-cell: 0.6 nTPM
  • MAIT T-cell: 0.4 nTPM
  • memory B-cell: 0.4 nTPM
  • gdT-cell: 0.3 nTPM

Brain region

  • thalamus: 52 nTPM
  • white matter: 41 nTPM
  • midbrain: 36 nTPM
  • medulla oblongata: 32 nTPM
  • cerebellum: 31 nTPM
  • hypothalamus: 31 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TMEM163.

Disease | AllUniProt

Conditions TMEM163 is implicated in, by any mechanism.

  • Leukodystrophy, hypomyelinating, 25 (HLD25) MIM:620243

Disease | GeneticClinVar

4 pathogenic / likely-pathogenic of 60 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Leukodystrophy, hypomyelinating, 25

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.85
gnomAD pLI
0.04
gnomAD missense Z
1.77
DepMap mean gene effect
-0.06
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TMEM163 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM163 as an antibody target. Whether an autoantibody or antibody against TMEM163 could matter depends on whether native TMEM163 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM163 is annotated at the cell surface, where native TMEM163 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TMEM163 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TMEM163. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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