Seroatlas · Human Serome Atlas

FUT8

Alpha-(1,6)-fucosyltransferase

Also known as: FUT8_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9BYC5
Gene
FUT8
Ensembl
ENSG00000033170
Chromosome
14
Canonical length
575 aa
Protein class
Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Nucleoplasm,Golgi apparatus,Cytosol

OverviewNCBI Gene

This gene encodes an enzyme belonging to the family of fucosyltransferases. The product of this gene catalyzes the transfer of fucose from GDP-fucose to N-linked type complex glycopeptides. This enzyme is distinct from other fucosyltransferases which catalyze alpha1-2, alpha1-3, and alpha1-4 fucose addition. The expression of this gene may contribute to the malignancy of cancer cells and to their invasive and metastatic capabilities. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2011]

Canonical amino-acid sequenceUniProt

575 residues, UniProt reviewed canonical sequence.

>Q9BYC5|FUT8
     1  MRPWTGSWRW IMLILFAWGT LLFYIGGHLV RDNDHPDHSS RELSKILAKL ERLKQQNEDL
    61  RRMAESLRIP EGPIDQGPAI GRVRVLEEQL VKAKEQIENY KKQTRNGLGK DHEILRRRIE
   121  NGAKELWFFL QSELKKLKNL EGNELQRHAD EFLLDLGHHE RSIMTDLYYL SQTDGAGDWR
   181  EKEAKDLTEL VQRRITYLQN PKDCSKAKKL VCNINKGCGY GCQLHHVVYC FMIAYGTQRT
   241  LILESQNWRY ATGGWETVFR PVSETCTDRS GISTGHWSGE VKDKNVQVVE LPIVDSLHPR
   301  PPYLPLAVPE DLADRLVRVH GDPAVWWVSQ FVKYLIRPQP WLEKEIEEAT KKLGFKHPVI
   361  GVHVRRTDKV GTEAAFHPIE EYMVHVEEHF QLLARRMQVD KKRVYLATDD PSLLKEAKTK
   421  YPNYEFISDN SISWSAGLHN RYTENSLRGV ILDIHFLSQA DFLVCTFSSQ VCRVAYEIMQ
   481  TLHPDASANF HSLDDIYYFG GQNAHNQIAI YAHQPRTADE IPMEPGDIIG VAGNHWDGYS
   541  KGVNRKLGRT GLYPSYKVRE KIETVKYPTY PEAEK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FUT8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.3
Highest tissue expression
40 nTPM

Expression across tissuesHPA

Tissue

  • salivary gland: 40 nTPM
  • spinal cord: 37 nTPM
  • stomach: 30 nTPM
  • cerebral cortex: 19 nTPM
  • hippocampal formation: 18 nTPM
  • tonsil: 17 nTPM

Single-cell type

  • oligodendrocytes: 1,155 nCPM
  • salivary acinar cells: 916 nCPM
  • mucous neck cells: 705 nCPM
  • plasma cells: 632 nCPM
  • foveolar cells: 545 nCPM
  • pituitary stem cells: 472 nCPM

Immune cell

  • memory B-cell: 16 nTPM
  • NK-cell: 15 nTPM
  • T-reg: 10 nTPM
  • naive B-cell: 8.3 nTPM
  • naive CD4 T-cell: 6.6 nTPM
  • naive CD8 T-cell: 6.6 nTPM

Brain region

  • white matter: 158 nTPM
  • cerebellum: 122 nTPM
  • basal ganglia: 108 nTPM
  • medulla oblongata: 100 nTPM
  • cerebral cortex: 96 nTPM
  • midbrain: 92 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about FUT8.

Disease | AllUniProt

Conditions FUT8 is implicated in, by any mechanism.

  • Congenital disorder of glycosylation with defective fucosylation 1 (CDGF1) MIM:618005

Disease | GeneticClinVar

8 pathogenic / likely-pathogenic of 181 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.51
gnomAD pLI
0.01
gnomAD missense Z
2.2
DepMap mean gene effect
0.04
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

  • SH3 domain binding
  • alpha-(1->6)-fucosyltransferase activity
  • glycoprotein 6-alpha-L-fucosyltransferase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • SH3 domain
  • SH3-like domain superfamily
  • Variant SH3 domain
  • Alpha-(1,6)-fucosyltransferase
  • Glycosyltransferase family 23 (GT23) domain
  • Alpha-(1,6)-fucosyltransferase, SH3 domain
  • Alpha-(1,6)-fucosyltransferase, N- and catalytic domain
  • Alpha-(1,6)-fucosyltransferase N- and catalytic domains

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FUT8 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FUT8 as an antibody target. Whether an autoantibody or antibody against FUT8 could matter depends on whether native FUT8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FUT8 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FUT8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FUT8. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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