Cation efflux protein, cytoplasmic domain
PF16916
Definition
This entry represents the cytoplasmic domain in Cation Diffusion Facilitator (CDD) transporter proteins including zinc transporters. These proteins are involved in the transport of divalent metal cations across cellular membranes. They facilitate the efflux or sequestration of metals such as zinc, cadmium, iron, manganese, and cobalt, contributing to metal homeostasis and detoxification. These proteins often function as antiporters, coupling the transport of metal ions with protons or other ions. They play crucial roles in various biological processes, including maintaining cellular metal ion balance, protecting cells from metal toxicity, and regulating metal ion concentrations in specific cellular compartments. These proteins include subfamilies like SCL30A, which are involved in zinc transport, and FieF, which is associated with metal detoxification. This domain is the dimerisation region of the whole molecule of zinc transporters since the full-length members form a homodimer during activity. The domain lies within the cytoplasm and exhibits an overall structural similarity with the copper metallochaperone Hah1 Swissprot:O00244, exhibiting an open alpha-beta domain with two alpha helices (H1 and H2) aligned on one side and a three-stranded mixed beta-sheet (S1 to S3) on the other side. The N-terminal domain is represented by [pfam:PF01545] PMID:17717154.
6 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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