Seroatlas · Human Serome Atlas

OCIAD1

OCIA domain-containing protein 1

Also known as: Asrij, FLJ20455, OCAD1_HUMAN, OCIA, TPA018

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NX40
Gene: OCIAD1
Ensembl: ENSG00000109180
Chromosome: 4
Canonical length: 245 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Vesicles

OverviewNCBI Gene

Predicted to be involved in several processes, including hematopoietic stem cell homeostasis; positive regulation of receptor signaling pathway via JAK-STAT; and regulation of stem cell differentiation. Located in membrane and mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

245 residues, UniProt reviewed canonical sequence.

>Q9NX40|OCIAD1
     1  MNGRADFREP NAEVPRPIPH IGPDYIPTEE ERRVFAECND ESFWFRSVPL AATSMLITQG
    61  LISKGILSSH PKYGSIPKLI LACIMGYFAG KLSYVKTCQE KFKKLENSPL GEALRSGQAR
   121  RSSPPGHYYQ KSKYDSSVSG QSSFVTSPAA DNIEMLPHYE PIPFSSSMNE SAPTGITDHI
   181  VQGPDPNLEE SPKRKNITYE ELRNKNRESY EVSLTQKTDP SVRPMHERVP KKEVKVNKYG
   241  DTWDE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OCIAD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.56
Highest tissue expression: 305 nTPM

Expression across tissuesHPA

Tissue

liver: 305 nTPM
tongue: 239 nTPM
skeletal muscle: 239 nTPM
parathyroid gland: 234 nTPM
thyroid gland: 224 nTPM
kidney: 222 nTPM

Single-cell type

parietal cells: 258 nCPM
esophageal apical cells: 250 nCPM
extravillous trophoblasts: 239 nCPM
fallopian tube ciliated cells: 227 nCPM
gastric chief cells: 225 nCPM
fallopian secretory cells: 223 nCPM

Immune cell

NK-cell: 96 nTPM
MAIT T-cell: 91 nTPM
naive CD4 T-cell: 90 nTPM
non-classical monocyte: 87 nTPM
plasmacytoid DC: 85 nTPM
naive CD8 T-cell: 81 nTPM

Brain region

hypothalamus: 201 nTPM
cerebral cortex: 198 nTPM
choroid plexus: 196 nTPM
white matter: 185 nTPM
basal ganglia: 184 nTPM
hippocampal formation: 181 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.07
gnomAD pLI: 0
gnomAD missense Z: 0.55
DepMap mean gene effect: 0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of OCIAD1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OCIAD1 as an antibody target. Whether an autoantibody or antibody against OCIAD1 could matter depends on whether native OCIAD1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OCIAD1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label OCIAD1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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