Seroatlas · Human Serome Atlas

DCAF12

DDB1- and CUL4-associated factor 12

Also known as: CT102, DCA12_HUMAN, DKFZP434O125, KIAA1892, MGC1058, TCC52, WDR40A

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5T6F0
Gene: DCAF12
Ensembl: ENSG00000198876
Chromosome: 9
Canonical length: 453 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a WD repeat-containing protein that interacts with the COP9 signalosome, a macromolecular complex that interacts with cullin-RING E3 ligases and regulates their activity by hydrolyzing cullin-Nedd8 conjugates. [provided by RefSeq, Jul 2009]

Canonical amino-acid sequenceUniProt

453 residues, UniProt reviewed canonical sequence.

>Q5T6F0|DCAF12
     1  MARKVVSRKR KAPASPGAGS DAQGPQFGWD HSLHKRKRLP PVKRSLVYYL KNREVRLQNE
    61  TSYSRVLHGY AAQQLPSLLK EREFHLGTLN KVFASQWLNH RQVVCGTKCN TLFVVDVQTS
   121  QITKIPILKD REPGGVTQQG CGIHAIELNP SRTLLATGGD NPNSLAIYRL PTLDPVCVGD
   181  DGHKDWIFSI AWISDTMAVS GSRDGSMGLW EVTDDVLTKS DARHNVSRVP VYAHITHKAL
   241  KDIPKEDTNP DNCKVRALAF NNKNKELGAV SLDGYFHLWK AENTLSKLLS TKLPYCRENV
   301  CLAYGSEWSV YAVGSQAHVS FLDPRQPSYN VKSVCSRERG SGIRSVSFYE HIITVGTGQG
   361  SLLFYDIRAQ RFLEERLSAC YGSKPRLAGE NLKLTTGKGW LNHDETWRNY FSDIDFFPNA
   421  VYTHCYDSSG TKLFVAGGPL PSGLHGNYAG LWS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DCAF12 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 58 nTPM

Expression across tissuesHPA

Tissue

testis: 58 nTPM
tonsil: 40 nTPM
lymph node: 35 nTPM
bone marrow: 32 nTPM
adrenal gland: 31 nTPM
esophagus: 29 nTPM

Single-cell type

erythrocytes: 402 nCPM
esophageal apical cells: 267 nCPM
early spermatids: 174 nCPM
kupffer cells: 129 nCPM
late primary spermatocytes: 125 nCPM
neutrophil progenitors: 75 nCPM

Immune cell

basophil: 37 nTPM
classical monocyte: 29 nTPM
eosinophil: 28 nTPM
neutrophil: 28 nTPM
myeloid DC: 25 nTPM
intermediate monocyte: 24 nTPM

Brain region

choroid plexus: 23 nTPM
medulla oblongata: 19 nTPM
white matter: 17 nTPM
spinal cord: 17 nTPM
midbrain: 17 nTPM
pons: 17 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about DCAF12.

Disease | ImmuneIEDB

Conditions an epitope on DCAF12 was assayed in.

colorectal cancer T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.86
gnomAD pLI: 0
gnomAD missense Z: 1.55
DepMap mean gene effect: -0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

ubiquitin-like ligase-substrate adaptor activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DCAF12 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DCAF12 as an antibody target. Whether an autoantibody or antibody against DCAF12 could matter depends on whether native DCAF12 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DCAF12 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DCAF12 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...