Seroatlas · Human Serome Atlas

MIA2

Melanoma inhibitory activity protein 2

Also known as: cTAGE-5A, cTAGE-5B, cTAGE-5C, cTAGE-5D, CTAGE5, FLJ22404, MEA6, MGEA, MGEA11, MGEA6, MIA2_HUMAN, TALI

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96PC5
Gene: MIA2
Ensembl: ENSG00000150527
Chromosome: 14
Canonical length: 1412 aa
Protein class: Disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location: Endoplasmic reticulum
Secretome location: Intracellular and membrane

OverviewNCBI Gene

This gene encodes s receptor in the endoplasmic reticulum, which plays a role in the export of large pre-chylomicrons and pre-very low density lipoproteins (pre-VLDLs). Three major classes of transcripts are generated from this gene- melanoma inhibitory activity 2-specific transcripts, cTAGE family member 5-specific transcripts and transcripts that include exons from both these transcript species (TANGO1-like or TALI). Additionally, alternative splicing in these transcripts results in multiple transcript variants encoding multiple isoforms. [provided by RefSeq, Sep 2016]

Canonical amino-acid sequenceUniProt

1412 residues, UniProt reviewed canonical sequence.

>Q96PC5|MIA2
     1  MAKFGVHRIL LLAISLTKCL ESTKLLADLK KCGDLECEAL INRVSAMRDY RGPDCRYLNF
    61  TKGEEISVYV KLAGEREDLW AGSKGKEFGY FPRDAVQIEE VFISEEIQMS TKESDFLCLL
   121  GVSYTFDNED SELNGDYGEN IYPYEEDKDE KSSIYESDFQ IEPGFYATYE STLFEDQVPA
   181  LEAPEDIGST SESKDWEEVV VESMEQDRIP EVHVPPSSAV SGVKEWFGLG GEQAEEKAFE
   241  SVIEPVQESS FRSRKIAVED ENDLEELNNG EPQTEHQQES ESEIDSVPKT QSELASESEH
   301  IPKPQSTGWF GGGFTSYLGF GDEDTGLELI AEESNPPLQD FPNSISSDKE ATVPCTEILT
   361  EKKDTITNDS LSLKPSWFDF GFAILGFAYA KEDKIMLDDR KNEEDGGADE HEHPLTSELD
   421  PEKEQEIETI KIIETEDQID KKPVSEKTDE SDTIPYLKKF LYNFDNPWNF QNIPKETELP
   481  FPKQILDQNN VIENEETGEF SIDNYPTDNT KVMIFKSSYS LSDMVSNIEL PTRIHEEVYF
   541  EPSSSKDSDE NSKPSVDTEG PALVEIDRSV ENTLLNSQMV STDNSLSSQN YISQKEDASE
   601  FQILKYLFQI DVYDFMNSAF SPIVILTERV VAALPEGMRP DSNLYGFPWE LVICAAVVGF
   661  FAVLFFLWRS FRSVRSRLYV GREKKLALML SGLIEEKSKL LEKFSLVQKE YEGYEVESSL
   721  KDASFEKEAT EAQSLEATCE KLNRSNSELE DEILCLEKEL KEEKSKHSEQ DELMADISKR
   781  IQSLEDESKS LKSQVAEAKM TFKIFQMNEE RLKIAIKDAL NENSQLQESQ KQLLQEAEVW
   841  KEQVSELNKQ KVTFEDSKVH AEQVLNDKES HIKTLTERLL KMKDWAAMLG EDITDDDNLE
   901  LEMNSESENG AYLDNPPKGA LKKLIHAAKL NASLKTLEGE RNQIYIQLSE VDKTKEELTE
   961  HIKNLQTEQA SLQSENTHFE NENQKLQQKL KVMTELYQEN EMKLHRKLTV EENYRLEKEE
  1021  KLSKVDEKIS HATEELETYR KRAKDLEEEL ERTIHSYQGQ IISHEKKAHD NWLAARNAER
  1081  NLNDLRKENA HNRQKLTETE LKFELLEKDP YALDVPNTAF GREHSPYGPS PLGWPSSETR
  1141  AFLSPPTLLE GPLRLSPLLP GGGGRGSRGP GNPLDHQITN ERGESSCDRL TDPHRAPSDT
  1201  GSLSPPWDQD RRMMFPPPGQ SYPDSALPPQ RQDRFCSNSG RLSGPAELRS FNMPSLDKMD
  1261  GSMPSEMESS RNDTKDDLGN LNVPDSSLPA ENEATGPGFV PPPLAPIRGP LFPVDARGPF
  1321  LRRGPPFPPP PPGAMFGASR DYFPPGDFPG PPPAPFAMRN VYPPRGFPPY LPPRPGFFPP
  1381  PPHSEGRSEF PSGLIPPSNE PATEHPEPQQ ET

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MIA2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.61
Highest tissue expression: 126 nTPM

Expression across tissuesHPA

Tissue

liver: 126 nTPM
choroid plexus: 82 nTPM
duodenum: 74 nTPM
small intestine: 72 nTPM
kidney: 71 nTPM
skeletal muscle: 51 nTPM

Single-cell type

myonuclei: 436 nCPM
enterocytes: 380 nCPM
proximal tubule cells: 367 nCPM
choroid plexus epithelial cells: 281 nCPM
neutrophils: 265 nCPM
cardiomyocytes: 228 nCPM

Immune cell

basophil: 41 nTPM
neutrophil: 35 nTPM
eosinophil: 26 nTPM
non-classical monocyte: 21 nTPM
intermediate monocyte: 18 nTPM
myeloid DC: 18 nTPM

Brain region

choroid plexus: 136 nTPM
hippocampal formation: 33 nTPM
cerebral cortex: 28 nTPM
hypothalamus: 28 nTPM
basal ganglia: 27 nTPM
white matter: 27 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.66
gnomAD pLI: 0
gnomAD missense Z: -0.58
DepMap mean gene effect: -0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MIA2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MIA2 as an antibody target. Whether an autoantibody or antibody against MIA2 could matter depends on whether native MIA2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MIA2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MIA2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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