Seroatlas · Human Serome Atlas

SLC9A7

Sodium/hydrogen exchanger 7

Also known as: NHE-7, NHE7, SL9A7_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96T83
Gene
SLC9A7
Ensembl
ENSG00000065923
Chromosome
X
Canonical length
725 aa
Protein class
Disease related genes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted membrane proteins, Transporters
Subcellular location
Vesicles

OverviewNCBI Gene

This gene encodes a sodium and potassium/ proton antiporter that is a member of the solute carrier family 9 protein family. The encoded protein is primarily localized to the trans-Golgi network and is involved in maintaining pH homeostasis in organelles along the secretory and endocytic pathways. This protein may enhance cell growth of certain breast tumors. This gene is part of a gene cluster on chromosome Xp11.23. A pseudogene of this gene is found on chromosome 12. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012]

Canonical amino-acid sequenceUniProt

725 residues, UniProt reviewed canonical sequence.

>Q96T83|SLC9A7
     1  MEPGDAARPG SGRATGAPPP RLLLLPLLLG WGLRVAAAAS ASSSGAAAED SSAMEELATE
    61  KEAEESHRQD SVSLLTFILL LTLTILTIWL FKHRRVRFLH ETGLAMIYGL IVGVILRYGT
   121  PATSGRDKSL SCTQEDRAFS TLLVNVSGKF FEYTLKGEIS PGKINSVEQN DMLRKVTFDP
   181  EVFFNILLPP IIFHAGYSLK KRHFFRNLGS ILAYAFLGTA VSCFIIGNLM YGVVKLMKIM
   241  GQLSDKFYYT DCLFFGAIIS ATDPVTVLAI FNELHADVDL YALLFGESVL NDAVAIVLSS
   301  SIVAYQPAGL NTHAFDAAAF FKSVGIFLGI FSGSFTMGAV TGVNANVTKF TKLHCFPLLE
   361  TALFFLMSWS TFLLAEACGF TGVVAVLFCG ITQAHYTYNN LSVESRSRTK QLFEVLHFLA
   421  ENFIFSYMGL ALFTFQKHVF SPIFIIGAFV AIFLGRAAHI YPLSFFLNLG RRHKIGWNFQ
   481  HMMMFSGLRG AMAFALAIRD TASYARQMMF TTTLLIVFFT VWIIGGGTTP MLSWLNIRVG
   541  VEEPSEEDQN EHHWQYFRVG VDPDQDPPPN NDSFQVLQGD GPDSARGNRT KQESAWIFRL
   601  WYSFDHNYLK PILTHSGPPL TTTLPAWCGL LARCLTSPQV YDNQEPLREE DSDFILTEGD
   661  LTLTYGDSTV TANGSSSSHT ASTSLEGSRR TKSSSEEVLE RDLGMGDQKV SSRGTRLVFP
   721  LEDNA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC9A7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
13
Mean surface accessibility (rSASA)
0.38
Highest tissue expression
29 nTPM

Expression across tissuesHPA

Tissue

  • basal ganglia: 29 nTPM
  • hypothalamus: 9.4 nTPM
  • pituitary gland: 8.7 nTPM
  • parathyroid gland: 8.4 nTPM
  • cerebellum: 8 nTPM
  • cerebral cortex: 8 nTPM

Single-cell type

  • gonadotrophs: 260 nCPM
  • cardiomyocytes: 219 nCPM
  • brain inhibitory neurons: 156 nCPM
  • hematopoietic stem cells: 153 nCPM
  • b-cells: 152 nCPM
  • pdcs: 151 nCPM

Immune cell

  • plasmacytoid DC: 2.7 nTPM
  • naive B-cell: 1.7 nTPM
  • memory B-cell: 1.6 nTPM
  • myeloid DC: 1.1 nTPM
  • neutrophil: 0.8 nTPM
  • NK-cell: 0.5 nTPM

Brain region

  • basal ganglia: 99 nTPM
  • hypothalamus: 48 nTPM
  • pons: 43 nTPM
  • medulla oblongata: 40 nTPM
  • cerebral cortex: 35 nTPM
  • thalamus: 31 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SLC9A7.

Disease | AllUniProt

Conditions SLC9A7 is implicated in, by any mechanism.

  • Intellectual developmental disorder, X-linked 108 (XLID108) MIM:301024

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 310 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Intellectual developmental disorder, X-linked 108
  • SLC9A7-related neurodevelopmental disorder

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.26
gnomAD pLI
0.99
gnomAD missense Z
2.12
DepMap mean gene effect
0.15
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SLC9A7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC9A7 as an antibody target. Whether an autoantibody or antibody against SLC9A7 could matter depends on whether native SLC9A7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC9A7 is annotated at the cell surface, where native SLC9A7 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC9A7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLC9A7. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...