Seroatlas · Human Serome Atlas

ANKRD13A

Ankyrin repeat domain-containing protein 13A

Also known as: AN13A_HUMAN, ANKRD13, NY-REN-25

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8IZ07
Gene
ANKRD13A
Ensembl
ENSG00000076513
Chromosome
12
Canonical length
590 aa
Protein class
Predicted intracellular proteins
Subcellular location
Plasma membrane

OverviewNCBI Gene

Enables ubiquitin-modified protein reader activity. Involved in negative regulation of protein localization to endosome and negative regulation of receptor internalization. Located in late endosome; perinuclear region of cytoplasm; and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

590 residues, UniProt reviewed canonical sequence.

>Q8IZ07|ANKRD13A
     1  MSSACDAGDH YPLHLLVWKN DYRQLEKELQ GQNVEAVDPR GRTLLHLAVS LGHLESARVL
    61  LRHKADVTKE NRQGWTVLHE AVSTGDPEMV YTVLQHRDYH NTSMALEGVP ELLQKILEAP
   121  DFYVQMKWEF TSWVPLVSRI CPNDVCRIWK SGAKLRVDIT LLGFENMSWI RGRRSFIFKG
   181  EDNWAELMEV NHDDKVVTTE RFDLSQEMER LTLDLMKPKS REVERRLTSP VINTSLDTKN
   241  IAFERTKSGF WGWRTDKAEV VNGYEAKVYT VNNVNVITKI RTEHLTEEEK KRYKADRNPL
   301  ESLLGTVEHQ FGAQGDLTTE CATANNPTAI TPDEYFNEEF DLKDRDIGRP KELTIRTQKF
   361  KAMLWMCEEF PLSLVEQVIP IIDLMARTSA HFARLRDFIK LEFPPGFPVK IEIPLFHVLN
   421  ARITFGNVNG CSTAEESVSQ NVEGTQADSA SHITNFEVDQ SVFEIPESYY VQDNGRNVHL
   481  QDEDYEIMQF AIQQSLLESS RSQELSGPAS NGGISQTNTY DAQYERAIQE SLLTSTEGLC
   541  PSALSETSRF DNDLQLAMEL SAKELEEWEL RLQEEEAELQ QVLQLSLTDK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ANKRD13A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.34
Highest tissue expression
62 nTPM

Expression across tissuesHPA

Tissue

  • tonsil: 62 nTPM
  • testis: 57 nTPM
  • lymph node: 50 nTPM
  • appendix: 34 nTPM
  • bone marrow: 34 nTPM
  • spleen: 31 nTPM

Single-cell type

  • neutrophils: 572 nCPM
  • late spermatids: 258 nCPM
  • neutrophil progenitors: 229 nCPM
  • late primary spermatocytes: 160 nCPM
  • esophageal apical cells: 151 nCPM
  • alveolar cells type 1: 147 nCPM

Immune cell

  • eosinophil: 5.7 nTPM
  • neutrophil: 3.5 nTPM
  • intermediate monocyte: 2.5 nTPM
  • memory B-cell: 2 nTPM
  • basophil: 1.5 nTPM
  • MAIT T-cell: 1.5 nTPM

Brain region

  • white matter: 32 nTPM
  • basal ganglia: 22 nTPM
  • medulla oblongata: 20 nTPM
  • cerebellum: 20 nTPM
  • midbrain: 19 nTPM
  • cerebral cortex: 19 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.57
gnomAD pLI
0
gnomAD missense Z
1.47
DepMap mean gene effect
-0.01
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ANKRD13A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ANKRD13A as an antibody target. Whether an autoantibody or antibody against ANKRD13A could matter depends on whether native ANKRD13A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ANKRD13A is annotated at the cell surface, where native ANKRD13A is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ANKRD13A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ANKRD13A. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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