Seroatlas · Human Serome Atlas

RSPO2

R-spondin-2

Also known as: MGC35555, RSPO2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6UXX9
Gene
RSPO2
Ensembl
ENSG00000147655
Chromosome
8
Canonical length
243 aa
Protein class
Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted secreted proteins
Secretome location
Secreted in other tissues

OverviewNCBI Gene

This gene encodes a member of the R-spondin family of proteins. These proteins are secreted ligands of leucine-rich repeat containing G protein-coupled receptors that enhance Wnt signaling through the inhibition of ubiquitin E3 ligases. A chromosomal translocation including this locus that results in the formation of a gene fusion has been identified in multiple human cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

Canonical amino-acid sequenceUniProt

243 residues, UniProt reviewed canonical sequence.

>Q6UXX9|RSPO2
     1  MQFRLFSFAL IILNCMDYSH CQGNRWRRSK RASYVSNPIC KGCLSCSKDN GCSRCQQKLF
    61  FFLRREGMRQ YGECLHSCPS GYYGHRAPDM NRCARCRIEN CDSCFSKDFC TKCKVGFYLH
   121  RGRCFDECPD GFAPLEETME CVEGCEVGHW SEWGTCSRNN RTCGFKWGLE TRTRQIVKKP
   181  VKDTILCPTI AESRRCKMTM RHCPGGKRTP KAKEKRNKKK KRKLIERAQE QHSVFLATDR
   241  ANQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RSPO2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.45
Highest tissue expression
17 nTPM

Expression across tissuesHPA

Tissue

  • placenta: 17 nTPM
  • cerebral cortex: 15 nTPM
  • midbrain: 13 nTPM
  • colon: 13 nTPM
  • prostate: 8.4 nTPM
  • hypothalamus: 8.1 nTPM

Single-cell type

  • oocytes: 189 nCPM
  • other brain neurons: 90 nCPM
  • ependymal cells: 59 nCPM
  • epicardial cells: 36 nCPM
  • brain excitatory neurons: 35 nCPM
  • brain inhibitory neurons: 23 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • midbrain: 52 nTPM
  • hypothalamus: 29 nTPM
  • cerebral cortex: 25 nTPM
  • white matter: 12 nTPM
  • hippocampal formation: 7.5 nTPM
  • thalamus: 6.1 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about RSPO2.

Disease | AllUniProt

Conditions RSPO2 is implicated in, by any mechanism.

  • Tetraamelia syndrome 2 (TETAMS2) MIM:618021
  • Humerofemoral hypoplasia with radiotibial ray deficiency (HHRRD) MIM:618022

Disease | GeneticClinVar

5 pathogenic / likely-pathogenic of 109 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Tetraamelia syndrome 2
  • Humerofemoral hypoplasia with radiotibial ray deficiency
  • Tetraamelia-multiple malformations syndrome

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.76
gnomAD pLI
0.02
gnomAD missense Z
0.5
DepMap mean gene effect
0.05
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RSPO2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RSPO2 as an antibody target. Whether an autoantibody or antibody against RSPO2 could matter depends on whether native RSPO2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RSPO2 is annotated as secreted, so native RSPO2 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label RSPO2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RSPO2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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