Seroatlas · Human Serome Atlas

WNT1

Proto-oncogene Wnt-1

Also known as: INT1, WNT1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P04628
Gene
WNT1
Ensembl
ENSG00000125084
Chromosome
12
Canonical length
370 aa
Protein class
Cancer-related genes, Disease related genes, Human disease related genes, Predicted secreted proteins
Secretome location
Secreted to extracellular matrix

OverviewNCBI Gene

The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is very conserved in evolution, and the protein encoded by this gene is known to be 98% identical to the mouse Wnt1 protein at the amino acid level. The studies in mouse indicate that the Wnt1 protein functions in the induction of the mesencephalon and cerebellum. This gene was originally considered as a candidate gene for Joubert syndrome, an autosomal recessive disorder with cerebellar hypoplasia as a leading feature. However, further studies suggested that the gene mutations might not have a significant role in Joubert syndrome. This gene is clustered with another family member, WNT10B, in the chromosome 12q13 region. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

370 residues, UniProt reviewed canonical sequence.

>P04628|WNT1
     1  MGLWALLPGW VSATLLLALA ALPAALAANS SGRWWGIVNV ASSTNLLTDS KSLQLVLEPS
    61  LQLLSRKQRR LIRQNPGILH SVSGGLQSAV RECKWQFRNR RWNCPTAPGP HLFGKIVNRG
   121  CRETAFIFAI TSAGVTHSVA RSCSEGSIES CTCDYRRRGP GGPDWHWGGC SDNIDFGRLF
   181  GREFVDSGEK GRDLRFLMNL HNNEAGRTTV FSEMRQECKC HGMSGSCTVR TCWMRLPTLR
   241  AVGDVLRDRF DGASRVLYGN RGSNRASRAE LLRLEPEDPA HKPPSPHDLV YFEKSPNFCT
   301  YSGRLGTAGT AGRACNSSSP ALDGCELLCC GRGHRTRTQR VTERCNCTFH WCCHVSCRNC
   361  THTRVLHECL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against WNT1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.33
Highest tissue expression
1.2 nTPM

Expression across tissuesHPA

Tissue

  • testis: 1.2 nTPM
  • bone marrow: 0.9 nTPM
  • basal ganglia: 0.8 nTPM
  • lymph node: 0.5 nTPM
  • small intestine: 0.5 nTPM
  • spleen: 0.5 nTPM

Single-cell type

  • early primary spermatocytes: 7.5 nCPM
  • extravillous trophoblasts: 5.4 nCPM
  • epicardial cells: 4.5 nCPM
  • t-cells: 3.3 nCPM
  • late primary spermatocytes: 2.3 nCPM
  • nk-cells: 1.9 nCPM

Immune cell

  • MAIT T-cell: 5.1 nTPM
  • gdT-cell: 3.1 nTPM
  • memory CD8 T-cell: 2.9 nTPM
  • naive CD8 T-cell: 2.1 nTPM
  • memory CD4 T-cell: 2 nTPM
  • total PBMC: 0.5 nTPM

Brain region

  • basal ganglia: 7.6 nTPM
  • cerebral cortex: 4.8 nTPM
  • hippocampal formation: 3 nTPM
  • amygdala: 2.7 nTPM
  • hypothalamus: 1.6 nTPM
  • white matter: 1.6 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about WNT1.

Disease | AllUniProt

Conditions WNT1 is implicated in, by any mechanism.

Disease | GeneticClinVar

47 pathogenic / likely-pathogenic of 297 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.6
gnomAD pLI
0.33
gnomAD missense Z
1.06
DepMap mean gene effect
-0.21
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of WNT1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads WNT1 as an antibody target. Whether an autoantibody or antibody against WNT1 could matter depends on whether native WNT1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

WNT1 is annotated as secreted, so native WNT1 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label WNT1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/WNT1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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