Seroatlas · Human Serome Atlas

LGR6

Leucine-rich repeat-containing G-protein coupled receptor 6

Also known as: FLJ14471, LGR6_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9HBX8
Gene: LGR6
Ensembl: ENSG00000133067
Chromosome: 1
Canonical length: 967 aa
Protein class: G-protein coupled receptors, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm,Plasma membrane

OverviewNCBI Gene

This gene encodes a member of the leucine-rich repeat-containing subgroup of the G protein-coupled 7-transmembrane protein superfamily. The encoded protein is a glycoprotein hormone receptor with a large N-terminal extracellular domain that contains leucine-rich repeats important for the formation of a horseshoe-shaped interaction motif for ligand binding. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

967 residues, UniProt reviewed canonical sequence.

>Q9HBX8|LGR6
     1  MPSPPGLRAL WLCAALCASR RAGGAPQPGP GPTACPAPCH CQEDGIMLSA DCSELGLSAV
    61  PGDLDPLTAY LDLSMNNLTE LQPGLFHHLR FLEELRLSGN HLSHIPGQAF SGLYSLKILM
   121  LQNNQLGGIP AEALWELPSL QSLRLDANLI SLVPERSFEG LSSLRHLWLD DNALTEIPVR
   181  ALNNLPALQA MTLALNRISH IPDYAFQNLT SLVVLHLHNN RIQHLGTHSF EGLHNLETLD
   241  LNYNKLQEFP VAIRTLGRLQ ELGFHNNNIK AIPEKAFMGN PLLQTIHFYD NPIQFVGRSA
   301  FQYLPKLHTL SLNGAMDIQE FPDLKGTTSL EILTLTRAGI RLLPSGMCQQ LPRLRVLELS
   361  HNQIEELPSL HRCQKLEEIG LQHNRIWEIG ADTFSQLSSL QALDLSWNAI RSIHPEAFST
   421  LHSLVKLDLT DNQLTTLPLA GLGGLMHLKL KGNLALSQAF SKDSFPKLRI LEVPYAYQCC
   481  PYGMCASFFK ASGQWEAEDL HLDDEESSKR PLGLLARQAE NHYDQDLDEL QLEMEDSKPH
   541  PSVQCSPTPG PFKPCEYLFE SWGIRLAVWA IVLLSVLCNG LVLLTVFAGG PVPLPPVKFV
   601  VGAIAGANTL TGISCGLLAS VDALTFGQFS EYGARWETGL GCRATGFLAV LGSEASVLLL
   661  TLAAVQCSVS VSCVRAYGKS PSLGSVRAGV LGCLALAGLA AALPLASVGE YGASPLCLPY
   721  APPEGQPAAL GFTVALVMMN SFCFLVVAGA YIKLYCDLPR GDFEAVWDCA MVRHVAWLIF
   781  ADGLLYCPVA FLSFASMLGL FPVTPEAVKS VLLVVLPLPA CLNPLLYLLF NPHFRDDLRR
   841  LRPRAGDSGP LAYAAAGELE KSSCDSTQAL VAFSDVDLIL EASEAGRPPG LETYGFPSVT
   901  LISCQQPGAP RLEGSHCVEP EGNHFGNPQP SMDGELLLRA EGSTPAGGGL SGGGGFQPSG
   961  LAFASHV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LGR6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 67 nTPM

Expression across tissuesHPA

Tissue

blood vessel: 67 nTPM
pituitary gland: 17 nTPM
heart muscle: 14 nTPM
fallopian tube: 8.3 nTPM
midbrain: 8.3 nTPM
testis: 6.9 nTPM

Single-cell type

pituicytes/fscs: 632 nCPM
bergmann glia: 260 nCPM
pituitary stem cells: 232 nCPM
ependymal cells: 76 nCPM
vascular smooth muscle cells: 72 nCPM
respiratory basal cells: 41 nCPM

Immune cell

gdT-cell: 16 nTPM
memory CD8 T-cell: 9.1 nTPM
naive CD8 T-cell: 4.8 nTPM
total PBMC: 3.4 nTPM
memory CD4 T-cell: 1.7 nTPM
MAIT T-cell: 1 nTPM

Brain region

medulla oblongata: 31 nTPM
thalamus: 21 nTPM
pons: 18 nTPM
cerebellum: 18 nTPM
midbrain: 17 nTPM
hypothalamus: 15 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.64
gnomAD pLI: 0
gnomAD missense Z: 1.07
DepMap mean gene effect: -0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LGR6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LGR6 as an antibody target. Whether an autoantibody or antibody against LGR6 could matter depends on whether native LGR6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LGR6 is annotated at the cell surface, where native LGR6 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label LGR6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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