Rhomboid domain

Definition

This domain is found in a family of integral membrane proteins that are related to Drosophila rhomboid protein [swissprot:P20350]. Members of this family are mainly found in bacteria and eukaryotes. Rhomboid promotes the cleavage of the membrane-anchored TGF-alpha-like growth factor Spitz, allowing it to activate the Drosophila EGF receptor. Analysis has shown that Rhomboid-1 is an intramembrane serine protease [[cite:PMID:11672525],[cite:PMID:12620104],[cite:PMID:15684070]] ([ec:3.4.21.105]). Parasite-encoded rhomboid enzymes are also important for invasion of host cells by Toxoplasma and the malaria parasite PMID:15753289. This domain shows six transmembrane helices.

9 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (9 proteins: gene, accession, name)

• PARL
• RHBDD1
• RHBDD2
• RHBDD3
• RHBDF1
• RHBDF2
• RHBDL1
• RHBDL2
• RHBDL3