PTCRA

Protein identityUniProt · HPA

UniProt accession

Q6ISU1

Gene

PTCRA

Ensembl

ENSG00000171611

Chromosome

6

Canonical length

281 aa

Protein class

Predicted membrane proteins

OverviewNCBI Gene

The protein encoded by this gene is a single-pass type I membrane protein that is found in immmature but not mature T-cells. Along with TCRB and CD3 complex, the encoded protein forms the pre-T-cell receptor complex, which regulates early T-cell development. Four transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011]

Canonical amino-acid sequenceUniProt

281 residues, UniProt reviewed canonical sequence.

>Q6ISU1|PTCRA
     1  MAGTWLLLLL ALGCPALPTG VGGTPFPSLA PPIMLLVDGK QQMVVVCLVL DVAPPGLDSP
    61  IWFSAGNGSA LDAFTYGPSP ATDGTWTNLA HLSLPSEELA SWEPLVCHTG PGAEGHSRST
   121  QPMHLSGEAS TARTCPQEPL RGTPGGALWL GVLRLLLFKL LLFDLLLTCS CLCDPAGPLP
   181  SPATTTRLRA LGSHRLHPAT ETGGREATSS PRPQPRDRRW GDTPPGRKPG SPVWGEGSYL
   241  SSYPTCPAQA WCSRSALRAP SSSLGAFFAG DLPPPLQAGA A

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PTCRA can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.54

Highest tissue expression

120 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PTCRA.

Disease | AllUniProt

Conditions PTCRA is implicated in, by any mechanism.

• Immunodeficiency 126 (IMD126) MIM:620931

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 51 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Immunodeficiency 126, susceptibility to

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.08

gnomAD pLI

0.14

gnomAD missense Z

0.1

DepMap mean gene effect

-0.06

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• alpha-beta T cell differentiation
• negative regulation of thymocyte apoptotic process

Cellular components

• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• Immunoglobulin-like fold
• Immunoglobulin-like domain superfamily
• Pre-T-cell antigen receptor
• Pre-T-cell antigen receptor

KeywordsUniProt

• Cell membrane
• Disulfide bond
• Glycoprotein
• Membrane
• Receptor
• Signal
• Transmembrane
• Transmembrane helix

InteractionsUniProt · HPA

Protein binding partners of PTCRA in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• RHBDD1