Seroatlas · Human Serome Atlas

RUNDC3B

RUN domain-containing protein 3B

Also known as: RPIB9, RPIP9, RUN3B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96NL0
Gene
RUNDC3B
Ensembl
ENSG00000105784
Chromosome
7
Canonical length
473 aa
Protein class
Predicted intracellular proteins
Subcellular location
Intermediate filaments,Primary cilium,Basal body

OverviewNCBI Gene

No narrative summary is available for RUNDC3B in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

473 residues, UniProt reviewed canonical sequence.

>Q96NL0|RUNDC3B
     1  MASRSLGGLS GIRGGGGGGG KKSLSARNAA VERRNLITVC RFSVKTLIDR SCFETIDDSS
    61  PEFNNFAAIL EQILSHRLKE ISQSCRWLAH LQIPLQGQVT WFGYESPRSF WDYIRVACRK
   121  VSQNCICSIE NMENVSSSRA KGRAWIRVAL MEKHLSEYIS TALRDFKTTR RFYEDGAIVL
   181  GEEANMLAGM LLGLNAIDFS FCLKGEGLDG SFPAVIDYTP YLKYIQSSDS ISSDEEELRT
   241  LGSSGSESST PENVGPPFLM DENSWFNKCK RVKQKYQLTL EQKGYLEELL RLRENQLSES
   301  VSQNKILLQR IEDSDLAHKL EKEQLEYIIV ELQDQLTVLK NNDLRSRQEL TAHLTNQWPS
   361  PGALDVNAVA LDTLLYRKHN KQWYEKSYQS LDQLSAEVSL SQTSLDPGQS QEGDGKQDTL
   421  NVMSEGKEDT PSLLGLCGSL TSVASYKSLT SLKSNDYLAS PTTEMTSPGL TPS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RUNDC3B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.49
Highest tissue expression
7.8 nTPM

Expression across tissuesHPA

Tissue

  • adrenal gland: 7.8 nTPM
  • liver: 5.6 nTPM
  • cerebellum: 5 nTPM
  • cerebral cortex: 4.3 nTPM
  • duodenum: 2.5 nTPM
  • small intestine: 2.5 nTPM

Single-cell type

  • adrenal cortex cells: 376 nCPM
  • brain inhibitory neurons: 228 nCPM
  • retinal ganglion cells: 220 nCPM
  • brain excitatory neurons: 206 nCPM
  • other brain neurons: 188 nCPM
  • hematopoietic stem cells: 166 nCPM

Immune cell

  • gdT-cell: 0.3 nTPM
  • memory CD8 T-cell: 0.2 nTPM
  • naive CD8 T-cell: 0.2 nTPM
  • MAIT T-cell: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM

Brain region

  • cerebellum: 22 nTPM
  • hypothalamus: 17 nTPM
  • cerebral cortex: 17 nTPM
  • basal ganglia: 15 nTPM
  • pons: 14 nTPM
  • medulla oblongata: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.63
gnomAD pLI
0
gnomAD missense Z
0.91
DepMap mean gene effect
0.07
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RUNDC3B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RUNDC3B as an antibody target. Whether an autoantibody or antibody against RUNDC3B could matter depends on whether native RUNDC3B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RUNDC3B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RUNDC3B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RUNDC3B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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