Seroatlas · Human Serome Atlas

RABGGTB

Geranylgeranyl transferase type-2 subunit beta

Also known as: PGTB2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P53611
Gene
RABGGTB
Ensembl
ENSG00000137955
Chromosome
1
Canonical length
331 aa
Protein class
Enzymes, Predicted intracellular proteins
Subcellular location
Vesicles

OverviewNCBI Gene

This gene encodes the beta-subunit of the enzyme Rab geranylgeranyl-transferase (RabGGTase), which belongs to the protein prenyltransferase family. RabGGTase catalyzes the post-translational addition of geranylgeranyl groups to C-terminal cysteine residues of Rab GTPases. Three small nucleolar RNA genes are present in the intronic regions of this gene. Alternately spliced transcript variants have been observed for this gene. A pseudogene associated with this gene is located on chromosome 3. [provided by RefSeq, Jan 2013]

Canonical amino-acid sequenceUniProt

331 residues, UniProt reviewed canonical sequence.

>P53611|RABGGTB
     1  MGTPQKDVII KSDAPDTLLL EKHADYIASY GSKKDDYEYC MSEYLRMSGI YWGLTVMDLM
    61  GQLHRMNREE ILAFIKSCQH ECGGISASIG HDPHLLYTLS AVQILTLYDS INVIDVNKVV
   121  EYVKGLQKED GSFAGDIWGE IDTRFSFCAV ATLALLGKLD AINVEKAIEF VLSCMNFDGG
   181  FGCRPGSESH AGQIYCCTGF LAITSQLHQV NSDLLGWWLC ERQLPSGGLN GRPEKLPDVC
   241  YSWWVLASLK IIGRLHWIDR EKLRNFILAC QDEETGGFAD RPGDMVDPFH TLFGIAGLSL
   301  LGEEQIKPVN PVFCMPEEVL QRVNVQPELV S

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RABGGTB can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.22
Highest tissue expression
81 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 81 nTPM
  • tongue: 78 nTPM
  • kidney: 71 nTPM
  • choroid plexus: 67 nTPM
  • pancreas: 67 nTPM
  • liver: 63 nTPM

Single-cell type

  • parietal cells: 120 nCPM
  • esophageal basal cells: 116 nCPM
  • suprabasal keratinocytes: 106 nCPM
  • esophageal apical cells: 103 nCPM
  • esophageal suprabasal cells: 101 nCPM
  • gastric progenitor cells: 101 nCPM

Immune cell

  • myeloid DC: 12 nTPM
  • intermediate monocyte: 11 nTPM
  • plasmacytoid DC: 11 nTPM
  • memory B-cell: 9.6 nTPM
  • naive CD4 T-cell: 9.4 nTPM
  • MAIT T-cell: 9.3 nTPM

Brain region

  • spinal cord: 33 nTPM
  • white matter: 33 nTPM
  • hypothalamus: 28 nTPM
  • cerebellum: 28 nTPM
  • medulla oblongata: 28 nTPM
  • basal ganglia: 27 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.68
gnomAD pLI
0.01
gnomAD missense Z
1.48
DepMap mean gene effect
-1.48
DepMap dependency class
pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RABGGTB in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RABGGTB as an antibody target. Whether an autoantibody or antibody against RABGGTB could matter depends on whether native RABGGTB is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RABGGTB is annotated at the cell surface, where native RABGGTB is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label RABGGTB as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RABGGTB. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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