Seroatlas · Human Serome Atlas

PTAR1

Protein prenyltransferase alpha subunit repeat-containing protein 1

Also known as: PTAR1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7Z6K3
Gene: PTAR1
Ensembl: ENSG00000188647
Chromosome: 9
Canonical length: 402 aa
Protein class: Predicted intracellular proteins
Subcellular location: Centriolar satellite,Rods & Rings

OverviewNCBI Gene

Predicted to enable protein prenyltransferase activity. Predicted to contribute to Rab geranylgeranyltransferase activity. Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

402 residues, UniProt reviewed canonical sequence.

>Q7Z6K3|PTAR1
     1  MAETSEEVAV LVQRVVKDIT NAFRRNPHID EIGLIPCPEA RYNRSPIVLV ENKLGVESWC
    61  VKFLLPYVHN KLLLYRTRKQ WLNRDELIDV TCTLLLLNPD FTTAWNVRKE LILSGTLNPI
   121  KDLHLGKLAL TKFPKSPETW IHRRWVLQQL IQETSLPSFV TKGNLGTIPT ERAQRLIQEE
   181  MEVCGEAAGR YPSNYNAWSH RIWVLQHLAK LDVKILLDEL SSTKHWASMH VSDHSGFHYR
   241  QFLLKSLISQ TVIDSSVMEQ NPLRSEPALV PPKDEEAAVS TEEPRINLPH LLEEEVEFST
   301  DLIDSYPGHE TLWCHRRHIF YLQHHLNAGS QLSQAMEVDG LNDSSKQGYS QETKRLKRTP
   361  VPDSLGLEME HRFIDQVLST CRNVEQARFA SAYRKWLVTL SQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PTAR1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 32 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 32 nTPM
retina: 20 nTPM
thymus: 19 nTPM
parathyroid gland: 15 nTPM
kidney: 13 nTPM
liver: 12 nTPM

Single-cell type

neutrophil progenitors: 176 nCPM
choroid plexus epithelial cells: 168 nCPM
myonuclei: 147 nCPM
neutrophils: 142 nCPM
astrocytes: 130 nCPM
pituitary stem cells: 117 nCPM

Immune cell

neutrophil: 7.4 nTPM
basophil: 5.6 nTPM
eosinophil: 4.3 nTPM
T-reg: 4.3 nTPM
intermediate monocyte: 3.3 nTPM
naive CD8 T-cell: 2.9 nTPM

Brain region

thalamus: 49 nTPM
white matter: 42 nTPM
medulla oblongata: 42 nTPM
midbrain: 41 nTPM
amygdala: 40 nTPM
choroid plexus: 39 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.39
gnomAD pLI: 0.86
gnomAD missense Z: 1.44
DepMap mean gene effect: -0.28
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

protein prenyltransferase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PTAR1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

RABGGTB

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PTAR1 as an antibody target. Whether an autoantibody or antibody against PTAR1 could matter depends on whether native PTAR1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PTAR1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PTAR1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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