Seroatlas · Human Serome Atlas

PTP4A2

Protein tyrosine phosphatase type IVA 2

Also known as: HU-PP-1, OV-1, PRL-2, PRL2, ptp-IV1a, PTP4A, PTPCAAX2, TP4A2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q12974
Gene
PTP4A2
Ensembl
ENSG00000184007
Chromosome
1
Canonical length
167 aa
Protein class
Enzymes, Predicted intracellular proteins

OverviewNCBI Gene

The protein encoded by this gene belongs to a small class of the protein tyrosine phosphatase (PTP) family. PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. PTPs in this class contain a protein tyrosine phosphatase catalytic domain and a characteristic C-terminal prenylation motif. This PTP has been shown to primarily associate with plasmic and endosomal membrane through its C-terminal prenylation. This PTP was found to interact with the beta-subunit of Rab geranylgeranyltransferase II (beta GGT II), and thus may function as a regulator of GGT II activity. Overexpression of this gene in mammalian cells conferred a transformed phenotype, which suggested its role in tumorigenesis. Alternatively spliced transcript variants have been described. Related pseudogenes exist on chromosomes 11, 12 and 17. [provided by RefSeq, Aug 2010]

Canonical amino-acid sequenceUniProt

167 residues, UniProt reviewed canonical sequence.

>Q12974|PTP4A2
     1  MNRPAPVEIS YENMRFLITH NPTNATLNKF TEELKKYGVT TLVRVCDATY DKAPVEKEGI
    61  HVLDWPFDDG APPPNQIVDD WLNLLKTKFR EEPGCCVAVH CVAGLGRAPV LVALALIECG
   121  MKYEDAVQFI RQKRRGAFNS KQLLYLEKYR PKMRLRFRDT NGHCCVQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PTP4A2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.29
Highest tissue expression
456 nTPM

Expression across tissuesHPA

Tissue

  • thymus: 456 nTPM
  • spinal cord: 290 nTPM
  • midbrain: 288 nTPM
  • bone marrow: 279 nTPM
  • skeletal muscle: 279 nTPM
  • hippocampal formation: 226 nTPM

Single-cell type

  • platelets: 486 nCPM
  • urothelial cells: 327 nCPM
  • neutrophils: 281 nCPM
  • megakaryocytes: 229 nCPM
  • prostatic club cells: 187 nCPM
  • prostatic hillock cells: 159 nCPM

Immune cell

  • basophil: 205 nTPM
  • non-classical monocyte: 149 nTPM
  • intermediate monocyte: 106 nTPM
  • eosinophil: 88 nTPM
  • memory CD8 T-cell: 85 nTPM
  • gdT-cell: 75 nTPM

Brain region

  • white matter: 662 nTPM
  • basal ganglia: 502 nTPM
  • midbrain: 435 nTPM
  • amygdala: 401 nTPM
  • spinal cord: 398 nTPM
  • pons: 396 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.28
gnomAD pLI
0.97
gnomAD missense Z
2.07
DepMap mean gene effect
-0.29
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PTP4A2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PTP4A2 as an antibody target. Whether an autoantibody or antibody against PTP4A2 could matter depends on whether native PTP4A2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PTP4A2 is annotated at the cell surface, where native PTP4A2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PTP4A2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PTP4A2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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