Seroatlas · Human Serome Atlas

PTPRE

Receptor-type tyrosine-protein phosphatase epsilon

Also known as: PTPE, PTPRE_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P23469
Gene
PTPRE
Ensembl
ENSG00000132334
Chromosome
10
Canonical length
700 aa
Protein class
Enzymes, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Intermediate filaments
Quaternary structure
Homodimer

OverviewNCBI Gene

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Several alternatively spliced transcript variants of this gene have been reported, at least two of which encode a receptor-type PTP that possesses a short extracellular domain, a single transmembrane region, and two tandem intracytoplasmic catalytic domains; another one encodes a PTP that contains a distinct hydrophilic N-terminus, and thus represents a nonreceptor-type isoform of this PTP. Studies of the similar gene in mice suggested the regulatory roles of this PTP in RAS related signal transduction pathways, cytokine-induced SATA signaling, as well as the activation of voltage-gated K+ channels. [provided by RefSeq, Oct 2015]

Canonical amino-acid sequenceUniProt

700 residues, UniProt reviewed canonical sequence.

>P23469|PTPRE
     1  MEPLCPLLLV GFSLPLARAL RGNETTADSN ETTTTSGPPD PGASQPLLAW LLLPLLLLLL
    61  VLLLAAYFFR FRKQRKAVVS TSDKKMPNGI LEEQEQQRVM LLSRSPSGPK KYFPIPVEHL
   121  EEEIRIRSAD DCKQFREEFN SLPSGHIQGT FELANKEENR EKNRYPNILP NDHSRVILSQ
   181  LDGIPCSDYI NASYIDGYKE KNKFIAAQGP KQETVNDFWR MVWEQKSATI VMLTNLKERK
   241  EEKCHQYWPD QGCWTYGNIR VCVEDCVVLV DYTIRKFCIQ PQLPDGCKAP RLVSQLHFTS
   301  WPDFGVPFTP IGMLKFLKKV KTLNPVHAGP IVVHCSAGVG RTGTFIVIDA MMAMMHAEQK
   361  VDVFEFVSRI RNQRPQMVQT DMQYTFIYQA LLEYYLYGDT ELDVSSLEKH LQTMHGTTTH
   421  FDKIGLEEEF RKLTNVRIMK ENMRTGNLPA NMKKARVIQI IPYDFNRVIL SMKRGQEYTD
   481  YINASFIDGY RQKDYFIATQ GPLAHTVEDF WRMIWEWKSH TIVMLTEVQE REQDKCYQYW
   541  PTEGSVTHGE ITIEIKNDTL SEAISIRDFL VTLNQPQARQ EEQVRVVRQF HFHGWPEIGI
   601  PAEGKGMIDL IAAVQKQQQQ TGNHPITVHC SAGAGRTGTF IALSNILERV KAEGLLDVFQ
   661  AVKSLRLQRP HMVQTLEQYE FCYKVVQDFI DIFSDYANFK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PTPRE can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.3
Highest tissue expression
44 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 44 nTPM
  • appendix: 24 nTPM
  • spleen: 19 nTPM
  • adrenal gland: 16 nTPM
  • lymph node: 15 nTPM
  • lung: 15 nTPM

Single-cell type

  • neutrophils: 1,932 nCPM
  • lymphatic endothelial cells: 746 nCPM
  • monocytes: 700 nCPM
  • microglia: 624 nCPM
  • pdcs: 528 nCPM
  • neutrophil progenitors: 511 nCPM

Immune cell

  • neutrophil: 643 nTPM
  • plasmacytoid DC: 478 nTPM
  • classical monocyte: 177 nTPM
  • basophil: 176 nTPM
  • eosinophil: 148 nTPM
  • myeloid DC: 99 nTPM

Brain region

  • white matter: 41 nTPM
  • cerebral cortex: 40 nTPM
  • hippocampal formation: 40 nTPM
  • amygdala: 39 nTPM
  • medulla oblongata: 36 nTPM
  • hypothalamus: 33 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.47
gnomAD pLI
0
gnomAD missense Z
2.08
DepMap mean gene effect
0.06
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PTPRE in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PTPRE as an antibody target. Whether an autoantibody or antibody against PTPRE could matter depends on whether native PTPRE is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PTPRE is annotated at the cell surface, where native PTPRE is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PTPRE as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PTPRE. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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