Seroatlas · Human Serome Atlas

SNX19

Sorting nexin-19

Also known as: CHET8, KIAA0254, SNX19_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q92543
Gene
SNX19
Ensembl
ENSG00000120451
Chromosome
11
Canonical length
992 aa
Protein class
Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Mitochondria

OverviewNCBI Gene

Islet antigen-2 (IA-2) is an autoantigen in type 1 diabetes and plays a role in insulin secretion. IA-2 is found in dense-core secretory vesicles and interacts with the product of this gene, a sorting nexin. In mouse pancreatic beta-cells, the encoded protein influenced insulin secretion by stabilizing the number of dense-core secretory vesicles. [provided by RefSeq, Dec 2016]

Canonical amino-acid sequenceUniProt

992 residues, UniProt reviewed canonical sequence.

>Q92543|SNX19
     1  MKTETVPPFQ ETPAGSSCHL NNLLSSRKLM AVGVLLGWLL VIHLLVNVWL LCLLSALLVV
    61  LGGWLGSSLA GVASGRLHLE RFIPLATCPP CPEAERQLER EINRTIQMII RDFVLSWYRS
   121  VSQEPAFEEE MEAAMKGLVQ ELRRRMSVMD SHAVAQSVLT LCGCHLQSYI QAKEATAGKN
   181  GPVEPSHLWE AYCRATAPHP AVHSPSAEVT YTRGVVNLLL QGLVPKPHLE TRTGRHVVVE
   241  LITCNVILPL ISRLSDPDWI HLVLVGIFSK ARDPAPCPAS APEQPSVPTS LPLIAEVEQL
   301  PEGRASPVAA PVFLSYSEPE GSAGPSPEVE EGHEAVEGDL GGMCEERKVG NNSSHFLQPN
   361  VRGPLFLCED SELESPLSEL GKETIMLMTP GSFLSDRIQD ALCALESSQA LEPKDGEASE
   421  GAEAEEGPGT ETETGLPVST LNSCPEIHID TADKEIEQGD VTASVTALLE GPEKTCPSRP
   481  SCLEKDLTND VSSLDPTLPP VLLSSSPPGP LSSATFSFEP LSSPDGPVII QNLRITGTIT
   541  AREHSGTGFH PYTLYTVKYE TALDGENSSG LQQLAYHTVN RRYREFLNLQ TRLEEKPDLR
   601  KFIKNVKGPK KLFPDLPLGN MDSDRVEARK SLLESFLKQL CAIPEIANSE EVQEFLALNT
   661  DARIAFVKKP FMVSRIDKMV VSAIVDTLKT AFPRSEPQSP TEELSEAETE SKPQTEGKKA
   721  SKSRLRFSSS KISPALSVTE AQDKILYCLQ EGNVESETLS MSAMESFIEK QTKLLEMQPT
   781  KAPEKDPEQP PKGRVDSCVS DAAVPAQDPS NSDPGTETEL ADTALDLLLL LLTEQWKWLC
   841  TENMQKFLRL IFGTLVQRWL EVQVANLTSP QRWVQYLLLL QESIWPGGVL PKFPRPVRTQ
   901  EQKLAAEKQA LQSLMGVLPD LVVEILGVNK CRLSWGLVLE SLQQPLINRH LIYCLGDIIL
   961  EFLDLSASVE ESAATTSASD TPGNSKRMGV SS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SNX19 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.48
Highest tissue expression
20 nTPM

Expression across tissuesHPA

Tissue

  • thyroid gland: 20 nTPM
  • skeletal muscle: 20 nTPM
  • testis: 20 nTPM
  • blood vessel: 19 nTPM
  • salivary gland: 18 nTPM
  • smooth muscle: 18 nTPM

Single-cell type

  • adrenal medulla cells: 117 nCPM
  • thyrotrophs: 113 nCPM
  • corticotrophs: 104 nCPM
  • somatotrophs: 103 nCPM
  • adrenal cortex cells: 100 nCPM
  • retinal pigment epithelial cells: 98 nCPM

Immune cell

  • basophil: 6.5 nTPM
  • non-classical monocyte: 4 nTPM
  • classical monocyte: 3.6 nTPM
  • total PBMC: 3.5 nTPM
  • intermediate monocyte: 3.2 nTPM
  • MAIT T-cell: 3 nTPM

Brain region

  • medulla oblongata: 80 nTPM
  • white matter: 79 nTPM
  • thalamus: 74 nTPM
  • basal ganglia: 72 nTPM
  • spinal cord: 70 nTPM
  • midbrain: 70 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.86
gnomAD pLI
0
gnomAD missense Z
-0.58
DepMap mean gene effect
-0.12
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SNX19 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SNX19 as an antibody target. Whether an autoantibody or antibody against SNX19 could matter depends on whether native SNX19 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SNX19 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Source-annotated serology context

The source annotations explicitly mention antibody, autoantibody, autoantigen, or autoimmune context. This is biological context, not study-specific reactivity.

  • Islet antigen-2 (IA-2) is an autoantigen in type 1 diabetes and plays a role in insulin secretion.

Canonical record: https://seroatlas.com/gene/SNX19. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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