Seroatlas · Human Serome Atlas

PTPRA

Receptor-type tyrosine-protein phosphatase alpha

Also known as: HLPR, HPTPA, LRP, PTPA, PTPRA_HUMAN, PTPRL2, RPTPA

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P18433
Gene: PTPRA
Ensembl: ENSG00000132670
Chromosome: 20
Canonical length: 802 aa
Protein class: Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm,Vesicles

OverviewNCBI Gene

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. This PTP has been shown to dephosphorylate and activate Src family tyrosine kinases, and is implicated in the regulation of integrin signaling, cell adhesion and proliferation. Three alternatively spliced variants of this gene, which encode two distinct isoforms, have been reported. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

802 residues, UniProt reviewed canonical sequence.

>P18433|PTPRA
     1  MDSWFILVLL GSGLICVSAN NATTVAPSVG ITRLINSSTA EPVKEEAKTS NPTSSLTSLS
    61  VAPTFSPNIT LGPTYLTTVN SSDSDNGTTR TASTNSIGIT ISPNGTWLPD NQFTDARTEP
   121  WEGNSSTAAT TPETFPPSGN SDSKDRRDET PIIAVMVALS SLLVIVFIII VLYMLRFKKY
   181  KQAGSHSNSF RLSNGRTEDV EPQSVPLLAR SPSTNRKYPP LPVDKLEEEI NRRMADDNKL
   241  FREEFNALPA CPIQATCEAA SKEENKEKNR YVNILPYDHS RVHLTPVEGV PDSDYINASF
   301  INGYQEKNKF IAAQGPKEET VNDFWRMIWE QNTATIVMVT NLKERKECKC AQYWPDQGCW
   361  TYGNIRVSVE DVTVLVDYTV RKFCIQQVGD MTNRKPQRLI TQFHFTSWPD FGVPFTPIGM
   421  LKFLKKVKAC NPQYAGAIVV HCSAGVGRTG TFVVIDAMLD MMHTERKVDV YGFVSRIRAQ
   481  RCQMVQTDMQ YVFIYQALLE HYLYGDTELE VTSLETHLQK IYNKIPGTSN NGLEEEFKKL
   541  TSIKIQNDKM RTGNLPANMK KNRVLQIIPY EFNRVIIPVK RGEENTDYVN ASFIDGYRQK
   601  DSYIASQGPL LHTIEDFWRM IWEWKSCSIV MLTELEERGQ EKCAQYWPSD GLVSYGDITV
   661  ELKKEEECES YTVRDLLVTN TRENKSRQIR QFHFHGWPEV GIPSDGKGMI SIIAAVQKQQ
   721  QQSGNHPITV HCSAGAGRTG TFCALSTVLE RVKAEGILDV FQTVKSLRLQ RPHMVQTLEQ
   781  YEFCYKVVQE YIDAFSDYAN FK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PTPRA can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 94 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 94 nTPM
basal ganglia: 82 nTPM
amygdala: 80 nTPM
cerebellum: 79 nTPM
parathyroid gland: 78 nTPM
hippocampal formation: 73 nTPM

Single-cell type

bergmann glia: 303 nCPM
myonuclei: 295 nCPM
brain excitatory neurons: 294 nCPM
ependymal cells: 290 nCPM
nk-cells: 286 nCPM
lactotrophs: 281 nCPM

Immune cell

gdT-cell: 5.9 nTPM
basophil: 5.7 nTPM
memory B-cell: 5.1 nTPM
MAIT T-cell: 4.8 nTPM
naive CD8 T-cell: 4.8 nTPM
T-reg: 4.8 nTPM

Brain region

cerebral cortex: 180 nTPM
thalamus: 170 nTPM
basal ganglia: 156 nTPM
hippocampal formation: 155 nTPM
amygdala: 149 nTPM
cerebellum: 148 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PTPRA.

Disease | ImmuneIEDB

Conditions an epitope on PTPRA was assayed in.

glioblastoma T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.19
gnomAD pLI: 1
gnomAD missense Z: 2.67
DepMap mean gene effect: -0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 13% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PTPRA in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PTPRA as an antibody target. Whether an autoantibody or antibody against PTPRA could matter depends on whether native PTPRA is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PTPRA is annotated at the cell surface, where native PTPRA is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PTPRA as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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