MAP3K13

Protein identityUniProt · HPA

UniProt accession

O43283

Gene

MAP3K13

Ensembl

ENSG00000073803

Chromosome

3

Canonical length

966 aa

Protein class

Cancer-related genes, Enzymes, Predicted intracellular proteins

Subcellular location

Nucleoplasm,Centriolar satellite,Cytosol

Quaternary structure

Homodimer

OverviewNCBI Gene

The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase contains a dual leucine-zipper motif, and has been shown to form dimers/oligomers through its leucine-zipper motif. This kinase can phosphorylate and activate MAPK8/JNK, MAP2K7/MKK7, which suggests a role in the JNK signaling pathway. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

966 residues, UniProt reviewed canonical sequence.

>O43283|MAP3K13
     1  MANFQEHLSC SSSPHLPFSE SKTFNGLQDE LTAMGNHPSP KLLEDQQEKG MVRTELIESV
    61  HSPVTTTVLT SVSEDSRDQF ENSVLQLREH DESETAVSQG NSNTVDGEST SGTEDIKIQF
   121  SRSGSGSGGF LEGLFGCLRP VWNIIGKAYS TDYKLQQQDT WEVPFEEISE LQWLGSGAQG
   181  AVFLGKFRAE EVAIKKVREQ NETDIKHLRK LKHPNIIAFK GVCTQAPCYC IIMEYCAHGQ
   241  LYEVLRAGRK ITPRLLVDWS TGIASGMNYL HLHKIIHRDL KSPNVLVTHT DAVKISDFGT
   301  SKELSDKSTK MSFAGTVAWM APEVIRNEPV SEKVDIWSFG VVLWELLTGE IPYKDVDSSA
   361  IIWGVGSNSL HLPVPSTCPD GFKILMKQTW QSKPRNRPSF RQTLMHLDIA SADVLATPQE
   421  TYFKSQAEWR EEVKKHFEKI KSEGTCIHRL DEELIRRRRE ELRHALDIRE HYERKLERAN
   481  NLYMELSAIM LQLEMREKEL IKREQAVEKK YPGTYKRHPV RPIIHPNAME KLMKRKGVPH
   541  KSGMQTKRPD LLRSEGIPTT EVAPTASPLS GSPKMSTSSS KSRYRSKPRH RRGNSRGSHS
   601  DFAAILKNQP AQENSPHPTY LHQAQSQYPS LHHHNSLQQQ YQQPPPAMSQ SHHPRLNMHG
   661  QDIATCANNL RYFGPAAALR SPLSNHAQRQ LPGSSPDLIS TAMAADCWRS SEPDKGQAGP
   721  WGCCQADAYD PCLQCRPEQY GSLDIPSAEP VGRSPDLSKS PAHNPLLENA QSSEKTEENE
   781  FSGCRSESSL GTSHLGTPPA LPRKTRPLQK SGDDSSEEEE GEVDSEVEFP RRQRPHRCIS
   841  SCQSYSTFSS ENFSVSDGEE GNTSDHSNSP DELADKLEDR LAEKLDDLLS QTPEIPIDIS
   901  SHSDGLSDKE CAVRRVKTQM SLGKLCVEER GYENPMQFEE SDCDSSDGEC SDATVRTNKH
   961  YSSATW

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MAP3K13 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.55

Highest tissue expression

54 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.34

gnomAD pLI

0.8

gnomAD missense Z

2.19

DepMap mean gene effect

-0.03

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• JNK cascade
• positive regulation of axon extension
• positive regulation of neuron maturation
• positive regulation of neuron projection arborization
• positive regulation of NF-kappaB transcription factor activity
• protein autophosphorylation
• protein phosphorylation
• stress-activated MAPK cascade
• positive regulation of branching morphogenesis of a nerve

Molecular functions

• ATP binding
• enzyme binding
• identical protein binding
• IkappaB kinase complex binding
• MAP kinase kinase kinase activity
• metal ion binding
• protein homodimerization activity
• protein kinase binding
• protein serine kinase activity
• protein serine/threonine kinase activator activity
• protein serine/threonine kinase activity

Cellular components

• cytoplasm
• membrane

Protein domainsUniProt · Pfam · InterPro

• Protein kinase domain
• Serine-threonine/tyrosine-protein kinase, catalytic domain
• Serine/threonine-protein kinase, active site
• Protein kinase-like domain superfamily
• Mitogen-activated protein kinase kinase kinase 12/13
• Serine/Threonine Kinases and Pseudokinases
• Protein tyrosine and serine/threonine kinase
• Mitogen-activated protein kinase kinase kinase 13

KeywordsUniProt

• ATP-binding
• Cytoplasm
• Kinase
• Magnesium
• Membrane
• Metal-binding
• Nucleotide-binding
• Phosphoprotein
• Repeat
• Serine/threonine-protein kinase
• Transferase

InteractionsUniProt · HPA

Protein binding partners of MAP3K13 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• PRDX3