PRDX2

Protein identityUniProt · HPA

UniProt accession

P32119

Gene

PRDX2

Ensembl

ENSG00000167815

Chromosome

19

Canonical length

198 aa

Protein class

Cancer-related genes, Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins

Subcellular location

Cytosol

Quaternary structure

Homodimer

OverviewNCBI Gene

This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein plays an antioxidant protective role in cells, and it may contribute to the antiviral activity of CD8(+) T-cells. The crystal structure of this protein has been resolved to 2.7 angstroms. This protein prevents hemolytic anemia from oxidative stress by stabilizing hemoglobin, thus making this gene a therapeutic target for patients with hemolytic anemia. This protein may have a proliferative effect and play a role in cancer development or progression. Related pseudogenes have been identified on chromosomes 5, 6, 10 and 13. [provided by RefSeq, Mar 2013]

Canonical amino-acid sequenceUniProt

198 residues, UniProt reviewed canonical sequence.

>P32119|PRDX2
     1  MASGNARIGK PAPDFKATAV VDGAFKEVKL SDYKGKYVVL FFYPLDFTFV CPTEIIAFSN
    61  RAEDFRKLGC EVLGVSVDSQ FTHLAWINTP RKEGGLGPLN IPLLADVTRR LSEDYGVLKT
   121  DEGIAYRGLF IIDGKGVLRQ ITVNDLPVGR SVDEALRLVQ AFQYTDEHGE VCPAGWKPGS
   181  DTIKPNVDDS KEYFSKHN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRDX2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.27

Highest tissue expression

791 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.9

gnomAD pLI

0.09

gnomAD missense Z

1.05

DepMap mean gene effect

-0.3

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cell redox homeostasis
• cellular response to oxidative stress
• defense response to tumor cell
• extrinsic apoptotic signaling pathway
• hydrogen peroxide catabolic process
• leukocyte activation
• negative regulation of apoptotic process
• negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
• negative regulation of lipopolysaccharide-mediated signaling pathway
• negative regulation of T cell differentiation
• positive regulation of blood coagulation
• positive regulation of MAPK cascade
• regulation of apoptotic process
• regulation of hydrogen peroxide metabolic process
• removal of superoxide radicals
• respiratory burst involved in inflammatory response
• response to lipopolysaccharide
• response to oxidative stress
• T cell homeostasis
• T cell proliferation
• thymus development

Molecular functions

• antioxidant activity
• thioredoxin peroxidase activity

Cellular components

• cytoplasm
• cytosol
• extracellular exosome

Protein domainsUniProt · Pfam · InterPro

• Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant
• Thioredoxin domain
• Peroxiredoxin, C-terminal
• Peroxiredoxin, AhpC-type
• Thioredoxin-like superfamily
• Thiol-specific antioxidant peroxiredoxin
• AhpC/TSA family
• C-terminal domain of 1-Cys peroxiredoxin

KeywordsUniProt

• Acetylation
• Antioxidant
• Cytoplasm
• Disulfide bond
• Oxidoreductase
• Peroxidase
• Phosphoprotein
• Redox-active center

InteractionsUniProt · HPA

Protein binding partners of PRDX2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• TIPIN
• PRDX3