Seroatlas · Human Serome Atlas

CTNNBIP1

Beta-catenin-interacting protein 1

Also known as: CNBP1_HUMAN, ICAT, MGC15093

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NSA3
Gene: CTNNBIP1
Ensembl: ENSG00000178585
Chromosome: 1
Canonical length: 81 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

The protein encoded by this gene binds CTNNB1 and prevents interaction between CTNNB1 and TCF family members. The encoded protein is a negative regulator of the Wnt signaling pathway. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

81 residues, UniProt reviewed canonical sequence.

>Q9NSA3|CTNNBIP1
     1  MNREGAPGKS PEEMYIQQKV RVLLMLRKMG SNLTASEEEF LRTYAGVVNS QLSQLPPHSI
    61  DQGAEDVVMA FSRSETEDRR Q

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CTNNBIP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.51
Highest tissue expression: 410 nTPM

Expression across tissuesHPA

Tissue

skin: 410 nTPM
esophagus: 169 nTPM
vagina: 80 nTPM
epididymis: 73 nTPM
cervix: 71 nTPM
salivary gland: 49 nTPM

Single-cell type

esophageal apical cells: 3,782 nCPM
esophageal suprabasal cells: 1,437 nCPM
suprabasal keratinocytes: 458 nCPM
esophageal basal cells: 323 nCPM
epididymal principal cells: 263 nCPM
müller glia: 232 nCPM

Immune cell

eosinophil: 14 nTPM
NK-cell: 8.6 nTPM
myeloid DC: 6.5 nTPM
classical monocyte: 5.3 nTPM
neutrophil: 3.7 nTPM
basophil: 2.7 nTPM

Brain region

thalamus: 67 nTPM
cerebellum: 66 nTPM
pons: 64 nTPM
medulla oblongata: 53 nTPM
cerebral cortex: 53 nTPM
hypothalamus: 51 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CTNNBIP1.

Disease | ImmuneIEDB

Conditions an epitope on CTNNBIP1 was assayed in.

pancreatic ductal adenocarcinoma T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.38
gnomAD pLI: 0.02
gnomAD missense Z: 0.53
DepMap mean gene effect: -0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CTNNBIP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CTNNBIP1 as an antibody target. Whether an autoantibody or antibody against CTNNBIP1 could matter depends on whether native CTNNBIP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CTNNBIP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CTNNBIP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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