Seroatlas · Human Serome Atlas

HASPIN

Serine/threonine-protein kinase haspin

Also known as: GSG2, HASP_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TF76
Gene: HASPIN
Ensembl: ENSG00000177602
Chromosome: 17
Canonical length: 798 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Enables ATP binding activity and histone H3T3 kinase activity. Involved in several processes, including mitotic sister chromatid cohesion; mitotic spindle assembly checkpoint signaling; and protein localization to chromosome, centromeric region. Located in centrosome; nucleoplasm; and spindle. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

798 residues, UniProt reviewed canonical sequence.

>Q8TF76|HASPIN
     1  MAASLPGPGS RLFRTYGAAD GRRQRRPGRE AAQWFPPQDR RRFFNSSGSS DASIGDPSQS
    61  DDPDDPDDPD FPGSPVRRRR RRPGGRVPKD RPSLTVTPKR WKLRARPSLT VTPRRLGLRA
   121  RPPQKCSTPC GPLRLPPFPS RDSGRLSPDL SVCGQPRDGD ELGISASLFS SLASPCPGSP
   181  TPRDSVISIG TSACLVAASA VPSGLHLPEV SLDRASLPCS QEEATGGAKD TRMVHQTRAS
   241  LRSVLFGLMN SGTPEDSEFR ADGKNMRESC CKRKLVVGNG PEGPGLSSTG KRRATGQDSC
   301  QERGLQEAVR REHQEASVPK GRIVPRGIDR LERTRSSRKS KHQEATETSL LHSHRFKKGQ
   361  KLGKDSFPTQ DLTPLQNVCF WTKTRASFSF HKKKIVTDVS EVCSIYTTAT SLSGSLLSEC
   421  SNRPVMNRTS GAPSSWHSSS MYLLSPLNTL SISNKKASDA EKVYGECSQK GPVPFSHCLP
   481  TEKLQRCEKI GEGVFGEVFQ TIADHTPVAI KIIAIEGPDL VNGSHQKTFE EILPEIIISK
   541  ELSLLSGEVC NRTEGFIGLN SVHCVQGSYP PLLLKAWDHY NSTKGSANDR PDFFKDDQLF
   601  IVLEFEFGGI DLEQMRTKLS SLATAKSILH QLTASLAVAE ASLRFEHRDL HWGNVLLKKT
   661  SLKKLHYTLN GKSSTIPSCG LQVSIIDYTL SRLERDGIVV FCDVSMDEDL FTGDGDYQFD
   721  IYRLMKKENN NRWGEYHPYS NVLWLHYLTD KMLKQMTFKT KCNTPAMKQI KRKIQEFHRT
   781  MLNFSSATDL LCQHSLFK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HASPIN can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.49
Highest tissue expression: 6.8 nTPM

Expression across tissuesHPA

Tissue

testis: 6.8 nTPM
bone marrow: 5.7 nTPM
thymus: 5 nTPM
tonsil: 4.8 nTPM
lymph node: 3.9 nTPM
appendix: 1.7 nTPM

Single-cell type

late primary spermatocytes: 34 nCPM
early spermatids: 17 nCPM
late spermatids: 9.7 nCPM
monocyte progenitors: 7.1 nCPM
megakaryocyte progenitors: 6.6 nCPM
erythrocyte progenitors: 5 nCPM

Immune cell

eosinophil: 0.5 nTPM
naive B-cell: 0.5 nTPM
plasmacytoid DC: 0.3 nTPM
myeloid DC: 0.2 nTPM
naive CD4 T-cell: 0.2 nTPM
basophil: 0.1 nTPM

Brain region

choroid plexus: 0.7 nTPM
basal ganglia: 0.6 nTPM
thalamus: 0.6 nTPM
white matter: 0.6 nTPM
cerebral cortex: 0.4 nTPM
midbrain: 0.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.01
gnomAD pLI: 0
DepMap mean gene effect: -0.13
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Protein kinase domain
Protein kinase-like domain superfamily
Protein kinase, ATP binding site
Serine/threonine-protein kinase haspin, C-terminal
Haspin like kinase domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of HASPIN in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

PNMA2

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HASPIN as an antibody target. Whether an autoantibody or antibody against HASPIN could matter depends on whether native HASPIN is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HASPIN is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HASPIN as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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