Seroatlas · Human Serome Atlas

AKT3

RAC-gamma serine/threonine-protein kinase

Also known as: AKT3_HUMAN, PKBG, PRKBG, RAC-gamma

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9Y243
Gene
AKT3
Ensembl
ENSG00000117020
Chromosome
1
Canonical length
479 aa
Protein class
Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, RAS pathway related proteins
Subcellular location
Nucleoplasm,Golgi apparatus,Plasma membrane,Primary cilium,Basal body,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a member of the AKT, also called PKB, serine/threonine protein kinase family. AKT kinases are known to be regulators of cell signaling in response to insulin and growth factors. They are involved in a wide variety of biological processes including cell proliferation, differentiation, apoptosis, tumorigenesis, as well as glycogen synthesis and glucose uptake. This kinase has been shown to be stimulated by platelet-derived growth factor (PDGF), insulin, and insulin-like growth factor 1 (IGF1). Alternatively splice transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

479 residues, UniProt reviewed canonical sequence.

>Q9Y243|AKT3
     1  MSDVTIVKEG WVQKRGEYIK NWRPRYFLLK TDGSFIGYKE KPQDVDLPYP LNNFSVAKCQ
    61  LMKTERPKPN TFIIRCLQWT TVIERTFHVD TPEEREEWTE AIQAVADRLQ RQEEERMNCS
   121  PTSQIDNIGE EEMDASTTHH KRKTMNDFDY LKLLGKGTFG KVILVREKAS GKYYAMKILK
   181  KEVIIAKDEV AHTLTESRVL KNTRHPFLTS LKYSFQTKDR LCFVMEYVNG GELFFHLSRE
   241  RVFSEDRTRF YGAEIVSALD YLHSGKIVYR DLKLENLMLD KDGHIKITDF GLCKEGITDA
   301  ATMKTFCGTP EYLAPEVLED NDYGRAVDWW GLGVVMYEMM CGRLPFYNQD HEKLFELILM
   361  EDIKFPRTLS SDAKSLLSGL LIKDPNKRLG GGPDDAKEIM RHSFFSGVNW QDVYDKKLVP
   421  PFKPQVTSET DTRYFDEEFT AQTITITPPE KYDEDGMDCM DNERRPHFPQ FSYSASGRE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against AKT3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.29
Highest tissue expression
35 nTPM

Expression across tissuesHPA

Tissue

  • blood vessel: 35 nTPM
  • cerebral cortex: 24 nTPM
  • cerebellum: 23 nTPM
  • ovary: 22 nTPM
  • colon: 20 nTPM
  • endometrium: 20 nTPM

Single-cell type

  • bergmann glia: 1,046 nCPM
  • podocytes: 964 nCPM
  • oligodendrocyte progenitor cells: 830 nCPM
  • microglia: 765 nCPM
  • brain excitatory neurons: 760 nCPM
  • astrocytes: 671 nCPM

Immune cell

  • NK-cell: 1.4 nTPM
  • basophil: 1.1 nTPM
  • MAIT T-cell: 1.1 nTPM
  • classical monocyte: 0.7 nTPM
  • naive B-cell: 0.7 nTPM
  • gdT-cell: 0.6 nTPM

Brain region

  • cerebellum: 263 nTPM
  • cerebral cortex: 216 nTPM
  • white matter: 199 nTPM
  • thalamus: 187 nTPM
  • hippocampal formation: 172 nTPM
  • basal ganglia: 169 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about AKT3.

Disease | AllUniProt

Conditions AKT3 is implicated in, by any mechanism.

  • Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 2 (MPPH2) MIM:615937

Disease | GeneticClinVar

15 pathogenic / likely-pathogenic of 239 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.18
gnomAD pLI
1
gnomAD missense Z
3.95
DepMap mean gene effect
0.06
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of AKT3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads AKT3 as an antibody target. Whether an autoantibody or antibody against AKT3 could matter depends on whether native AKT3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

AKT3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label AKT3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/AKT3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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