Seroatlas · Human Serome Atlas

PKD2L1

Polycystin-2-like protein 1

Also known as: PCL, PK2L1_HUMAN, PKD2L, PKDL, TRPP3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9P0L9
Gene
PKD2L1
Ensembl
ENSG00000107593
Chromosome
10
Canonical length
805 aa
Protein class
Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters, Voltage-gated ion channels
Subcellular location
Plasma membrane,Actin filaments,Cytosol
Quaternary structure
Homotetramer

OverviewNCBI Gene

This gene encodes a member of the polycystin protein family. The encoded protein contains multiple transmembrane domains, and cytoplasmic N- and C-termini. The protein may be an integral membrane protein involved in cell-cell/matrix interactions. This protein functions as a calcium-regulated nonselective cation channel. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

Canonical amino-acid sequenceUniProt

805 residues, UniProt reviewed canonical sequence.

>Q9P0L9|PKD2L1
     1  MNAVGSPEGQ ELQKLGSGAW DNPAYSGPPS PHGTLRVCTI SSTGPLQPQP KKPEDEPQET
    61  AYRTQVSSCC LHICQGIRGL WGTTLTENTA ENRELYIKTT LRELLVYIVF LVDICLLTYG
   121  MTSSSAYYYT KVMSELFLHT PSDTGVSFQA ISSMADFWDF AQGPLLDSLY WTKWYNNQSL
   181  GHGSHSFIYY ENMLLGVPRL RQLKVRNDSC VVHEDFREDI LSCYDVYSPD KEEQLPFGPF
   241  NGTAWTYHSQ DELGGFSHWG RLTSYSGGGY YLDLPGSRQG SAEALRALQE GLWLDRGTRV
   301  VFIDFSVYNA NINLFCVLRL VVEFPATGGA IPSWQIRTVK LIRYVSNWDF FIVGCEVIFC
   361  VFIFYYVVEE ILELHIHRLR YLSSIWNILD LVVILLSIVA VGFHIFRTLE VNRLMGKLLQ
   421  QPNTYADFEF LAFWQTQYNN MNAVNLFFAW IKIFKYISFN KTMTQLSSTL ARCAKDILGF
   481  AVMFFIVFFA YAQLGYLLFG TQVENFSTFI KCIFTQFRII LGDFDYNAID NANRILGPAY
   541  FVTYVFFVFF VLLNMFLAII NDTYSEVKEE LAGQKDELQL SDLLKQGYNK TLLRLRLRKE
   601  RVSDVQKVLQ GGEQEIQFED FTNTLRELGH AEHEITELTA TFTKFDRDGN RILDEKEQEK
   661  MRQDLEEERV ALNTEIEKLG RSIVSSPQGK SGPEAARAGG WVSGEEFYML TRRVLQLETV
   721  LEGVVSQIDA VGSKLKMLER KGWLAPSPGV KEQAIWKHPQ PAPAVTPDPW GVQGGQESEV
   781  PYKREEEALE ERRLSRGEIP TLQRS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PKD2L1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
6
Mean surface accessibility (rSASA)
0.39
Highest tissue expression
12 nTPM

Expression across tissuesHPA

Tissue

  • retina: 12 nTPM
  • spleen: 7.6 nTPM
  • cerebral cortex: 3.6 nTPM
  • testis: 2.3 nTPM
  • lung: 2.2 nTPM
  • tonsil: 1.6 nTPM

Single-cell type

  • retinal horizontal cells: 86 nCPM
  • late spermatids: 35 nCPM
  • kupffer cells: 31 nCPM
  • early spermatids: 24 nCPM
  • podocytes: 17 nCPM
  • hofbauer cells: 16 nCPM

Immune cell

  • intermediate monocyte: 0.9 nTPM
  • classical monocyte: 0.8 nTPM
  • non-classical monocyte: 0.8 nTPM
  • neutrophil: 0.2 nTPM
  • total PBMC: 0.1 nTPM
  • basophil: 0 nTPM

Brain region

  • cerebral cortex: 2.2 nTPM
  • white matter: 1.5 nTPM
  • basal ganglia: 1.4 nTPM
  • hippocampal formation: 0.8 nTPM
  • midbrain: 0.7 nTPM
  • pons: 0.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.25
gnomAD pLI
0
gnomAD missense Z
0.07
DepMap mean gene effect
-0.1
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PKD2L1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PKD2L1 as an antibody target. Whether an autoantibody or antibody against PKD2L1 could matter depends on whether native PKD2L1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PKD2L1 is annotated at the cell surface, where native PKD2L1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PKD2L1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PKD2L1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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