Polycystin-1 like, PLAT/LH2 domain

Definition

This is the PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological functions remain poorly defined. In human, mutations in polycystin-1 (PKD1) and polycystin-2 (PKD2) have been shown to be the cause for autosomal dominant polycystic kidney disease (ADPKD) [[cite:PMID:15336986], [cite:PMID:12022474], [cite:PMID:11274246], [cite:PMID:15260985]]. The generally proposed function of PLAT/LH2 domains is to mediate interaction with lipids or membrane bound proteins PMID:10469604.

5 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (5 proteins: gene, accession, name)

• PKD1
• PKD1L1
• PKD1L2
• PKD1L3
• PKDREJ