DGKZ

Protein identityUniProt · HPA

UniProt accession

Q13574

Gene

DGKZ

Ensembl

ENSG00000149091

Chromosome

11

Canonical length

928 aa

Protein class

Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins

Subcellular location

Nuclear speckles

OverviewNCBI Gene

The protein encoded by this gene belongs to the eukaryotic diacylglycerol kinase family. It may attenuate protein kinase C activity by regulating diacylglycerol levels in intracellular signaling cascade and signal transduction. Alternative splicing occurs at this locus and multiple transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Nov 2010]

Canonical amino-acid sequenceUniProt

928 residues, UniProt reviewed canonical sequence.

>Q13574|DGKZ
     1  MEPRDGSPEA RSSDSESASA SSSGSERDAG PEPDKAPRRL NKRRFPGLRL FGHRKAITKS
    61  GLQHLAPPPP TPGAPCSESE RQIRSTVDWS ESATYGEHIW FETNVSGDFC YVGEQYCVAR
   121  MLKSVSRRKC AACKIVVHTP CIEQLEKINF RCKPSFRESG SRNVREPTFV RHHWVHRRRQ
   181  DGKCRHCGKG FQQKFTFHSK EIVAISCSWC KQAYHSKVSC FMLQQIEEPC SLGVHAAVVI
   241  PPTWILRARR PQNTLKASKK KKRASFKRKS SKKGPEEGRW RPFIIRPTPS PLMKPLLVFV
   301  NPKSGGNQGA KIIQSFLWYL NPRQVFDLSQ GGPKEALEMY RKVHNLRILA CGGDGTVGWI
   361  LSTLDQLRLK PPPPVAILPL GTGNDLARTL NWGGGYTDEP VSKILSHVEE GNVVQLDRWD
   421  LHAEPNPEAG PEDRDEGATD RLPLDVFNNY FSLGFDAHVT LEFHESREAN PEKFNSRFRN
   481  KMFYAGTAFS DFLMGSSKDL AKHIRVVCDG MDLTPKIQDL KPQCVVFLNI PRYCAGTMPW
   541  GHPGEHHDFE PQRHDDGYLE VIGFTMTSLA ALQVGGHGER LTQCREVVLT TSKAIPVQVD
   601  GEPCKLAASR IRIALRNQAT MVQKAKRRSA APLHSDQQPV PEQLRIQVSR VSMHDYEALH
   661  YDKEQLKEAS VPLGTVVVPG DSDLELCRAH IERLQQEPDG AGAKSPTCQK LSPKWCFLDA
   721  TTASRFYRID RAQEHLNYVT EIAQDEIYIL DPELLGASAR PDLPTPTSPL PTSPCSPTPR
   781  SLQGDAAPPQ GEELIEAAKR NDFCKLQELH RAGGDLMHRD EQSRTLLHHA VSTGSKDVVR
   841  YLLDHAPPEI LDAVEENGET CLHQAAALGQ RTICHYIVEA GASLMKTDQQ GDTPRQRAEK
   901  AQDTELAAYL ENRQHYQMIQ REDQETAV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DGKZ can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.34

Highest tissue expression

223 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about DGKZ.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 577 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• atypical cerebral palsy

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.38

gnomAD pLI

0.04

gnomAD missense Z

2.76

DepMap mean gene effect

-0.1

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cell migration
• diacylglycerol metabolic process
• glycerolipid metabolic process
• intracellular signal transduction
• lipid phosphorylation
• mitotic G1 DNA damage checkpoint signaling
• negative regulation of T cell receptor signaling pathway
• phosphatidic acid biosynthetic process
• phospholipase C-activating G protein-coupled receptor signaling pathway
• platelet activation

Molecular functions

• alkylglycerol kinase activity
• ATP binding
• ATP-dependent diacylglycerol kinase activity
• kinase activity
• lipid kinase activity
• zinc ion binding

Cellular components

• cytoplasm
• cytosol
• glutamatergic synapse
• lamellipodium
• nuclear speck
• nucleus
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• Diacylglycerol kinase, accessory domain
• Diacylglycerol kinase, catalytic domain
• Ankyrin repeat
• Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
• NAD kinase/diacylglycerol kinase-like domain superfamily
• Inorganic polyphosphate/ATP-NAD kinase, N-terminal
• Ankyrin repeat-containing domain superfamily
• Diacylglycerol kinase
• Diacylglycerol kinase iota-like domain
• Phorbol esters/diacylglycerol binding domain (C1 domain)
• Diacylglycerol kinase accessory domain
• Diacylglycerol kinase catalytic domain
• Ankyrin repeats (3 copies)
• Diacylglycerol kinase iota-like domain
• Diacylglycerol kinase zeta, second protein kinase C conserved region 1
• Diacylglycerol kinase zeta, first protein kinase C conserved region 1

KeywordsUniProt

• ANK repeat
• ATP-binding
• Cell membrane
• Cell projection
• Cytoplasm
• Kinase
• Lipid metabolism
• Membrane
• Metal-binding
• Nucleotide-binding
• Nucleus
• Phosphoprotein
• Repeat
• Transferase
• Zinc
• Zinc-finger

InteractionsUniProt · HPA

Protein binding partners of DGKZ in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• IRS1
• PIP5K1A
• SNTG1