PIP4K2C

Protein identityUniProt · HPA

UniProt accession

Q8TBX8

Gene

PIP4K2C

Ensembl

ENSG00000166908

Chromosome

12

Canonical length

421 aa

Protein class

Enzymes, Metabolic proteins, Predicted intracellular proteins

Subcellular location

Nucleoplasm,Plasma membrane,Cytosol

OverviewNCBI Gene

Enables 1-phosphatidylinositol-4-phosphate 5-kinase activity and identical protein binding activity. Involved in 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process; negative regulation of insulin receptor signaling pathway; and positive regulation of autophagosome assembly. Located in several cellular components, including autophagosome; cytosol; and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

421 residues, UniProt reviewed canonical sequence.

>Q8TBX8|PIP4K2C
     1  MASSSVPPAT VSAATAGPGP GFGFASKTKK KHFVQQKVKV FRAADPLVGV FLWGVAHSIN
    61  ELSQVPPPVM LLPDDFKASS KIKVNNHLFH RENLPSHFKF KEYCPQVFRN LRDRFGIDDQ
   121  DYLVSLTRNP PSESEGSDGR FLISYDRTLV IKEVSSEDIA DMHSNLSNYH QYIVKCHGNT
   181  LLPQFLGMYR VSVDNEDSYM LVMRNMFSHR LPVHRKYDLK GSLVSREASD KEKVKELPTL
   241  KDMDFLNKNQ KVYIGEEEKK IFLEKLKRDV EFLVQLKIMD YSLLLGIHDI IRGSEPEEEA
   301  PVREDESEVD GDCSLTGPPA LVGSYGTSPE GIGGYIHSHR PLGPGEFESF IDVYAIRSAE
   361  GAPQKEVYFM GLIDILTQYD AKKKAAHAAK TVKHGAGAEI STVHPEQYAK RFLDFITNIF
   421  A

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PIP4K2C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.34

Highest tissue expression

77 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.72

gnomAD pLI

0

gnomAD missense Z

1.47

DepMap mean gene effect

-0.08

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process
• negative regulation of insulin receptor signaling pathway
• phosphatidylinositol phosphate biosynthetic process
• positive regulation of autophagosome assembly
• regulation of autophagy

Molecular functions

• 1-phosphatidylinositol-4-phosphate 5-kinase activity
• 1-phosphatidylinositol-5-phosphate 4-kinase activity
• ATP binding
• identical protein binding

Cellular components

• autophagosome
• cytosol
• endoplasmic reticulum
• extracellular exosome
• nucleoplasm
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• Phosphatidylinositol-4-phosphate 4/5-kinase, core
• Phosphatidylinositol-4/5-phosphate 5/4-kinase
• Phosphatidylinositol-4-phosphate 4/5-kinase, C-terminal domain superfamily
• Phosphatidylinositol-4-phosphate 5-kinase, N-terminal
• Phosphatidylinositol-4-phosphate 5-Kinase

KeywordsUniProt

• Acetylation
• ATP-binding
• Cytoplasm
• Endoplasmic reticulum
• Kinase
• Lipid metabolism
• Nucleotide-binding
• Phosphoprotein
• Transferase

InteractionsUniProt · HPA

Protein binding partners of PIP4K2C in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• PIP5K1A
• PIP4K2A
• RIOK2