Seroatlas · Human Serome Atlas

MYCBP

c-Myc-binding protein

Also known as: AMY-1, MYCBP_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q99417
Gene: MYCBP
Ensembl: ENSG00000214114
Chromosome: 1
Canonical length: 103 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Mitochondria

OverviewNCBI Gene

The protein encoded by this gene binds to the N-terminus of the oncogenic protein C-MYC, enhancing the ability of C-MYC to activate E box-dependent transcription. The encoded protein is normally found in the cytoplasm, but it translocates to the nucleus during S phase of the cell cycle and associates with C-MYC. This protein may be involved in spermatogenesis. This gene can be silenced by microRNA-22. Two transcript variants, one protein-coding and the other probably not protein-coding, have been found for this gene. [provided by RefSeq, Nov 2011]

Canonical amino-acid sequenceUniProt

103 residues, UniProt reviewed canonical sequence.

>Q99417|MYCBP
     1  MAHYKAADSK REQFRRYLEK SGVLDTLTKV LVALYEEPEK PNSALDFLKH HLGAATPENP
    61  EIELLRLELA EMKEKYEAIV EENKKLKAKL AQYEPPQEEK RAE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MYCBP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.5
Highest tissue expression: 26 nTPM

Expression across tissuesHPA

Tissue

esophagus: 26 nTPM
fallopian tube: 26 nTPM
colon: 21 nTPM
rectum: 21 nTPM
small intestine: 20 nTPM
placenta: 18 nTPM

Single-cell type

early spermatids: 51 nCPM
fallopian tube ciliated cells: 32 nCPM
endometrial ciliated cells: 25 nCPM
megakaryocytes: 25 nCPM
late primary spermatocytes: 17 nCPM
epididymal efferent duct ciliated cells: 15 nCPM

Immune cell

eosinophil: 85 nTPM
neutrophil: 65 nTPM
plasmacytoid DC: 54 nTPM
basophil: 52 nTPM
myeloid DC: 41 nTPM
intermediate monocyte: 40 nTPM

Brain region

midbrain: 22 nTPM
medulla oblongata: 19 nTPM
white matter: 17 nTPM
pons: 16 nTPM
choroid plexus: 14 nTPM
cerebellum: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.49
gnomAD pLI: 0.84
gnomAD missense Z: 0.93
DepMap mean gene effect: -0.1
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

transcription coactivator activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

Associate of Myc 1

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MYCBP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MYCBP as an antibody target. Whether an autoantibody or antibody against MYCBP could matter depends on whether native MYCBP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MYCBP is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MYCBP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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