Seroatlas · Human Serome Atlas

RADX

RPA-related protein RADX

Also known as: CXorf57, FLJ10178, FLJ14191, RADX_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6NSI4
Gene: RADX
Ensembl: ENSG00000147231
Chromosome: X
Canonical length: 855 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nuclear speckles

OverviewNCBI Gene

Enables single-stranded DNA binding activity. Involved in negative regulation of double-strand break repair via homologous recombination. Located in nuclear speck and replication fork. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

855 residues, UniProt reviewed canonical sequence.

>Q6NSI4|RADX
     1  MSGESGQPEA GPSHAGLDWP NPERNRAGVP GGVIRRAGSQ GPRSWIQKVL EQIMDSPRQC
    61  VTPSEVVPVT VLAVQRYLLE DEPRDTVPKP PLYCYDVTIS DGVYQEKCYL DPSLNSLVYQ
   121  NILKVGIQMR ISRVSCLYNE KRIGQGILCI DNVHCGETSD SISLETPFRN RAHQEKPERP
   181  LRGGKSHYLA LWNNEDPYGD IWLTDKQPEE HNFSDTKIIS LSHLEMTWTN RRNFPALLVR
   241  ILHKSKLRYY GKPDKKMIEP YQTFLEVADS SGTVSVIMWN ALCPEWYKSL RVGLVLLLQD
   301  YSVKKSYPFR IQPVPVDPQI KLISTMEICL NLRDPPTNII IIPEKQVKPE WRLPKLNHRF
   361  TTRSELDDMP ENCICDVIGL LVFVGRVQRS KKKENREDFW SYRWIHIADG TSEQPFIVEL
   421  FSTSQPEIFE NIYPMAYFVC TQLKVVRNDN QVPKLLYLTT TNESGVFITG HRGQPYTYDA
   481  KVKNFIQWIR TKSDSGEQKN MVIGGYYPYP PVPETFSKYS SSIKVESLLT AISEVRKEIE
   541  DLQYREQKRI AIQGIITAIK YIPHSSATES ASASETLRNA NRPSTSQAAR VEIQERNGKR
   601  HQDDEPVNSQ YFQTTSTNLS LSNKIRILQG PHANPVAVPQ PGASVQTKGI KPGMPSIFNR
   661  RANINANLQG KARKTISDRW ESQLWREKKF GLIDHLHYSR VYPESIPRKF MFEHRKFLSD
   721  QYNSQPAKYV PPEGRPPKLD DFKSARSLGH FEVTILGLNH EIAIDVAFLP MYCPEDIRTS
   781  QIDTLLTSMN YSCAYPQDTT GNDRLPGPRA VAGDIIKAAT ELDRVHIVGI LDICNLGNNK
   841  VEVYLHKIYS PENTS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RADX can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 24 nTPM

Expression across tissuesHPA

Tissue

hypothalamus: 24 nTPM
pituitary gland: 19 nTPM
basal ganglia: 11 nTPM
adrenal gland: 6.8 nTPM
ovary: 5.4 nTPM
cerebral cortex: 4.5 nTPM

Single-cell type

lactotrophs: 100 nCPM
somatotrophs: 82 nCPM
gonadotrophs: 67 nCPM
corticotrophs: 60 nCPM
thyrotrophs: 58 nCPM
other brain neurons: 52 nCPM

Immune cell

memory B-cell: 1.8 nTPM
gdT-cell: 1.5 nTPM
naive CD4 T-cell: 1.5 nTPM
memory CD4 T-cell: 1.2 nTPM
naive B-cell: 1.2 nTPM
naive CD8 T-cell: 1.2 nTPM

Brain region

hypothalamus: 54 nTPM
pons: 9.9 nTPM
basal ganglia: 9.5 nTPM
white matter: 8 nTPM
midbrain: 7.3 nTPM
thalamus: 6.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.65
gnomAD pLI: 0
DepMap mean gene effect: 0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Nucleic acid-binding, OB-fold
RPA-related protein RADX
RPA-related protein RADX

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RADX in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RADX as an antibody target. Whether an autoantibody or antibody against RADX could matter depends on whether native RADX is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RADX is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RADX as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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