Seroatlas · Human Serome Atlas

RARG

Retinoic acid receptor gamma

Also known as: NR1B3, RAR-gamma, RARC, RARG_HUMAN, RARgamma

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P13631
Gene
RARG
Ensembl
ENSG00000172819
Chromosome
12
Canonical length
454 aa
Protein class
Cancer-related genes, FDA approved drug targets, Nuclear receptors, Plasma proteins, Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoplasm
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes a retinoic acid receptor that belongs to the nuclear hormone receptor family. Retinoic acid receptors (RARs) act as ligand-dependent transcriptional regulators. When bound to ligands, RARs activate transcription by binding as heterodimers to the retinoic acid response elements (RARE) found in the promoter regions of the target genes. In their unbound form, RARs repress transcription of their target genes. RARs are involved in various biological processes, including limb bud development, skeletal growth, and matrix homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

Canonical amino-acid sequenceUniProt

454 residues, UniProt reviewed canonical sequence.

>P13631|RARG
     1  MATNKERLFA AGALGPGSGY PGAGFPFAFP GALRGSPPFE MLSPSFRGLG QPDLPKEMAS
    61  LSVETQSTSS EEMVPSSPSP PPPPRVYKPC FVCNDKSSGY HYGVSSCEGC KGFFRRSIQK
   121  NMVYTCHRDK NCIINKVTRN RCQYCRLQKC FEVGMSKEAV RNDRNKKKKE VKEEGSPDSY
   181  ELSPQLEELI TKVSKAHQET FPSLCQLGKY TTNSSADHRV QLDLGLWDKF SELATKCIIK
   241  IVEFAKRLPG FTGLSIADQI TLLKAACLDI LMLRICTRYT PEQDTMTFSD GLTLNRTQMH
   301  NAGFGPLTDL VFAFAGQLLP LEMDDTETGL LSAICLICGD RMDLEEPEKV DKLQEPLLEA
   361  LRLYARRRRP SQPYMFPRML MKITDLRGIS TKGAERAITL KMEIPGPMPP LIREMLENPE
   421  MFEDDSSQPG PHPNASSEDE VPGGQGKGGL KSPA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RARG can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.41
Highest tissue expression
138 nTPM

Expression across tissuesHPA

Tissue

  • esophagus: 138 nTPM
  • skin: 115 nTPM
  • vagina: 68 nTPM
  • cervix: 65 nTPM
  • fallopian tube: 29 nTPM
  • salivary gland: 28 nTPM

Single-cell type

  • esophageal apical cells: 394 nCPM
  • esophageal suprabasal cells: 180 nCPM
  • esophageal basal cells: 112 nCPM
  • prostatic hillock cells: 89 nCPM
  • suprabasal keratinocytes: 85 nCPM
  • prostatic club cells: 63 nCPM

Immune cell

  • MAIT T-cell: 19 nTPM
  • gdT-cell: 7.4 nTPM
  • myeloid DC: 6.7 nTPM
  • memory CD4 T-cell: 6.5 nTPM
  • memory CD8 T-cell: 5.4 nTPM
  • naive CD4 T-cell: 5.2 nTPM

Brain region

  • cerebellum: 17 nTPM
  • choroid plexus: 12 nTPM
  • medulla oblongata: 11 nTPM
  • amygdala: 11 nTPM
  • midbrain: 10 nTPM
  • spinal cord: 10 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about RARG.

Disease | ImmuneIEDB

Conditions an epitope on RARG was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.24
gnomAD pLI
0.99
gnomAD missense Z
3.13
DepMap mean gene effect
-0.06
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RARG in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RARG as an antibody target. Whether an autoantibody or antibody against RARG could matter depends on whether native RARG is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RARG is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RARG as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RARG. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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