Seroatlas · Human Serome Atlas

NOXO1

NADPH oxidase organizer 1

Also known as: NOXO1_HUMAN, P41NOXA, P41NOXB, P41NOXC, SH3PXD5, SNX28

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NFA2
Gene: NOXO1
Ensembl: ENSG00000196408
Chromosome: 16
Canonical length: 376 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes an NADPH oxidase (NOX) organizer, which positively regulates NOX1 and NOX3. The protein contains a PX domain and two SH3 domains. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jun 2012]

Canonical amino-acid sequenceUniProt

376 residues, UniProt reviewed canonical sequence.

>Q8NFA2|NOXO1
     1  MAGPRYPVSV QGAALVQIKR LQTFAFSVRW SDGSDTFVRR SWDEFRQLKK TLKETFPVEA
    61  GLLRRSDRVL PKLLGQASLD APLLGRVGRT SRGLARLQLL ETYSRRLLAT AERVARSPTI
   121  TGFFAPQPLD LEPALPPGSR VILPTPEEQP LSRAAGRLSI HSLEAQSLRC LQPFCTQDTR
   181  DRPFQAQAQE SLDVLLRHPS GWWLVENEDR QTAWFPAPYL EEAAPGQGRE GGPSLGSSGP
   241  QFCASRAYES SRADELSVPA GARVRVLETS DRGWWLCRYG DRAGLLPAVL LRPEGLGALL
   301  SGTGFRGGDD PAGEARGFPE PSQATAPPPT VPTRPSPGAI QSRCCTVTRR ALERRPRRQG
   361  RPRGCVDSVP HPTTEQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NOXO1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.4
Highest tissue expression: 8.1 nTPM

Expression across tissuesHPA

Tissue

colon: 8.1 nTPM
rectum: 5.5 nTPM
cerebellum: 5.4 nTPM
testis: 4.6 nTPM
appendix: 4.4 nTPM
small intestine: 3.2 nTPM

Single-cell type

esophageal apical cells: 93 nCPM
breast lactating cells: 54 nCPM
colonocytes: 52 nCPM
enteric stem cells: 30 nCPM
submucosal glandular cells: 27 nCPM
enteric transient amplifying cells: 27 nCPM

Immune cell

basophil: 0.1 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

pons: 3.8 nTPM
cerebral cortex: 2.8 nTPM
choroid plexus: 2.4 nTPM
basal ganglia: 2.1 nTPM
cerebellum: 2 nTPM
white matter: 2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.62
gnomAD pLI: 0
gnomAD missense Z: -0.81
DepMap mean gene effect: -0.12
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

SH3 domain
Phox homology
SH3-like domain superfamily
PX domain superfamily
NADPH Oxidase and PX Domain-Containing
SH3 domain
NADPH oxidase organiser 1, second SH3 domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NOXO1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NOXO1 as an antibody target. Whether an autoantibody or antibody against NOXO1 could matter depends on whether native NOXO1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NOXO1 is annotated at the cell surface, where native NOXO1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label NOXO1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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