Seroatlas · Human Serome Atlas

DZANK1

Double zinc ribbon and ankyrin repeat-containing protein 1

Also known as: ANKRD64, bA189K21.8, C20orf12, C20orf84, dJ568F9.2, DZAN1_HUMAN, FLJ10600, FLJ30892

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NVP4
Gene: DZANK1
Ensembl: ENSG00000089091
Chromosome: 20
Canonical length: 752 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

This gene contains two ankyrin repeat-encoding regions. Ankyrin repeats are tandemly repeated modules of about 33 amino acids described as L-shaped structures consisting of a beta-hairpin and two alpha-helices. Ankyrin repeats occur in a large number of functionally diverse proteins, mainly from eukaryotes, and are known to function as protein-protein interaction domains. [provided by RefSeq, Dec 2018]

Canonical amino-acid sequenceUniProt

752 residues, UniProt reviewed canonical sequence.

>Q9NVP4|DZANK1
     1  MTAGSVCVPQ IIPLRVPQPG KANHEIDNNT LLEMKSDTPD VNIYYTLDGS KPEFLKRIGY
    61  GENNTFKYIK PITLPDGKIQ VKAIAVSKDC RQSGIVTKVF HVDYEPPNIV SPEDNVENVL
   121  KDSSRQEFKN GFVGSKLKKK YKNSENQRSW NVNLRKFPES PLEIPAYGGG SGSRPPTRQS
   181  QSPGFAHVSG QKCLTSTEIM RIQRETDFLK CAHCLAPRPS DPFARFCQEC GSPVPPIFGC
   241  RLPPPEGAQM GLCAECRSLV PMNTPICVVC EAPLALQLQP QASLHLKEKV ICRACGTGNP
   301  AHLRYCVTCE GALPSSQESM CSGDKAPPPP TQKGGTISCY RCGRWNLWEA SFCGWCGAML
   361  GIPAGCSVCP KCGASNHLSA RFCGSCGICV KSLVKLSLDR SLALAAEEPR PFSESLNIPL
   421  PRSDVGTKRD IGTQTVGLFY PSGKLLAKKE QELASQKQRQ EKMSDHKPLL TAISPGRGYW
   481  RRQLDHISAH LRCYAQNNPE FRALIAEPRM GKLISATVHE DGCEVSIRLN YSQVSNKNLY
   541  LNKAVNFSDH LLSSAAEGDG GLCGSRSSWV SDYSQSTSDT IEKIKRIKNF KTKTFQEKKE
   601  QLIPENRLLL KEVGPTGEGR VSVIEQLLDE GADPNCCDED NRPVITVAVM NKHHEAIPVL
   661  VQRGADIDQQ WGPLRNTALH EATLLGLAGR ESTATLLGCN ASIQKKNAGG QTAYDLALNT
   721  GDDLVTSLFA AKFGQGLEDQ LAQTRSLSLD DC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DZANK1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.46
Highest tissue expression: 5.9 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 5.9 nTPM
pituitary gland: 5.9 nTPM
fallopian tube: 5.3 nTPM
retina: 5.3 nTPM
testis: 4.7 nTPM
hypothalamus: 4.5 nTPM

Single-cell type

ependymal cells: 226 nCPM
respiratory ciliated cells: 195 nCPM
fallopian tube ciliated cells: 117 nCPM
thyrotrophs: 107 nCPM
endometrial ciliated cells: 100 nCPM
somatotrophs: 76 nCPM

Immune cell

basophil: 2.7 nTPM
memory B-cell: 1.2 nTPM
intermediate monocyte: 1 nTPM
neutrophil: 1 nTPM
NK-cell: 0.9 nTPM
eosinophil: 0.8 nTPM

Brain region

choroid plexus: 11 nTPM
midbrain: 9.2 nTPM
cerebral cortex: 8.3 nTPM
hypothalamus: 7.8 nTPM
medulla oblongata: 7.8 nTPM
basal ganglia: 7.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.17
gnomAD pLI: 0
gnomAD missense Z: -0.14
DepMap mean gene effect: 0.18
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Protein domainsUniProt · Pfam · InterPro

Ankyrin repeat
Ankyrin repeat-containing domain superfamily
Ankyrin repeats (3 copies)
Double zinc ribbon
Fn3 associated repeat
Double zinc ribbon and ankyrin repeat-containing protein
Double zinc ribbon
Fn3 associated

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DZANK1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

NINL

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DZANK1 as an antibody target. Whether an autoantibody or antibody against DZANK1 could matter depends on whether native DZANK1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DZANK1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DZANK1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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