Seroatlas · Human Serome Atlas

ATRAID

All-trans retinoic acid-induced differentiation factor

Also known as: APR3, ARAID_HUMAN, C2orf28, HSPC013, p18

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6UW56
Gene: ATRAID
Ensembl: ENSG00000138085
Chromosome: 2
Canonical length: 229 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

This gene is thought to be involved in apoptosis, and may also be involved in hematopoietic development and differentiation. The use of alternative splice sites and promotors result in multiple transcript variants encoding different isoforms.[provided by RefSeq, Dec 2009]

Canonical amino-acid sequenceUniProt

229 residues, UniProt reviewed canonical sequence.

>Q6UW56|ATRAID
     1  MAPHDPGSLT TLVPWAAALL LALGVERALA LPEICTQCPG SVQNLSKVAF YCKTTRELML
    61  HARCCLNQKG TILGLDLQNC SLEDPGPNFH QAHTTVIIDL QANPLKGDLA NTFRGFTQLQ
   121  TLILPQHVNC PGGINAWNTI TSYIDNQICQ GQKNLCNNTG DPEMCPENGS CVPDGPGLLQ
   181  CVCADGFHGY KCMRQGSFSL LMFFGILGAT TLSVSILLWA TQRRKAKTS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ATRAID can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.38
Highest tissue expression: 324 nTPM

Expression across tissuesHPA

Tissue

epididymis: 324 nTPM
choroid plexus: 160 nTPM
heart muscle: 145 nTPM
ovary: 143 nTPM
skeletal muscle: 140 nTPM
tongue: 130 nTPM

Single-cell type

epididymal principal cells: 618 nCPM
late primary spermatocytes: 464 nCPM
extravillous trophoblasts: 440 nCPM
decidual stromal cells: 413 nCPM
cytotrophoblasts: 313 nCPM
late spermatids: 298 nCPM

Immune cell

total PBMC: 444 nTPM
plasmacytoid DC: 295 nTPM
memory B-cell: 280 nTPM
T-reg: 279 nTPM
naive B-cell: 273 nTPM
myeloid DC: 252 nTPM

Brain region

choroid plexus: 69 nTPM
white matter: 52 nTPM
medulla oblongata: 51 nTPM
cerebellum: 46 nTPM
hypothalamus: 44 nTPM
spinal cord: 43 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.12
gnomAD pLI: 0
gnomAD missense Z: -1.02
DepMap mean gene effect: -0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

xenobiotic transmembrane transporter activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

EGF-like domain
All-trans retinoic acid-induced differentiation factor

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ATRAID in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ATRAID as an antibody target. Whether an autoantibody or antibody against ATRAID could matter depends on whether native ATRAID is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ATRAID is annotated at the cell surface, where native ATRAID is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ATRAID as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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