Seroatlas · Human Serome Atlas

SYAP1

Synapse-associated protein 1

Also known as: FLJ14495, PRO3113, SYAP1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96A49
Gene: SYAP1
Ensembl: ENSG00000169895
Chromosome: X
Canonical length: 352 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Golgi apparatus,Cytosol

OverviewNCBI Gene

Involved in several processes, including TORC2 signaling; cellular response to epidermal growth factor stimulus; and cellular response to peptide hormone stimulus. Located in several cellular components, including Golgi apparatus; cytoplasmic side of plasma membrane; and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

352 residues, UniProt reviewed canonical sequence.

>Q96A49|SYAP1
     1  MFRGLSSWLG LQQPVAGGGQ PNGDAPPEQP SETVAESAEE ELQQAGDQEL LHQAKDFGNY
    61  LFNFASAATK KITESVAETA QTIKKSVEEG KIDGIIDKTI IGDFQKEQKK FVEEQHTKKS
   121  EAAVPPWVDT NDEETIQQQI LALSADKRNF LRDPPAGVQF NFDFDQMYPV ALVMLQEDEL
   181  LSKMRFALVP KLVKEEVFWR NYFYRVSLIK QSAQLTALAA QQQAAGKEEK SNGREQDLPL
   241  AEAVRPKTPP VVIKSQLKTQ EDEEEISTSP GVSEFVSDAF DACNLNQEDL RKEMEQLVLD
   301  KKQEETAVLE EDSADWEKEL QQELQEYEVV TESEKRDENW DKEIEKMLQE EN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SYAP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.52
Highest tissue expression: 28 nTPM

Expression across tissuesHPA

Tissue

liver: 28 nTPM
bone marrow: 24 nTPM
adrenal gland: 24 nTPM
duodenum: 16 nTPM
kidney: 15 nTPM
parathyroid gland: 15 nTPM

Single-cell type

neutrophils: 2,222 nCPM
mast cells: 832 nCPM
monocytes: 518 nCPM
megakaryocyte-erythroid progenitors: 509 nCPM
late spermatids: 458 nCPM
esophageal apical cells: 435 nCPM

Immune cell

neutrophil: 12 nTPM
non-classical monocyte: 12 nTPM
T-reg: 11 nTPM
NK-cell: 10 nTPM
gdT-cell: 9.9 nTPM
eosinophil: 9.3 nTPM

Brain region

choroid plexus: 31 nTPM
white matter: 23 nTPM
cerebral cortex: 22 nTPM
thalamus: 22 nTPM
hypothalamus: 21 nTPM
medulla oblongata: 21 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.35
gnomAD pLI: 0.94
gnomAD missense Z: 1.16
DepMap mean gene effect: -0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SYAP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SYAP1 as an antibody target. Whether an autoantibody or antibody against SYAP1 could matter depends on whether native SYAP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SYAP1 is annotated at the cell surface, where native SYAP1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SYAP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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