Seroatlas · Human Serome Atlas

ANKS4B

Ankyrin repeat and SAM domain-containing protein 4B

Also known as: ANS4B_HUMAN, FLJ38819, HARP

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N8V4
Gene: ANKS4B
Ensembl: ENSG00000175311
Chromosome: 16
Canonical length: 417 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Involved in brush border assembly; protein localization to microvillus; and protein-containing complex assembly. Located in brush border and microvillus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

417 residues, UniProt reviewed canonical sequence.

>Q8N8V4|ANKS4B
     1  MSTRYHQAAS DSYLELLKEA TKRDLNLSDE DGMTPTLLAA YHGNLEALEI ICSRGGDPDR
    61  CDIWGNTPLH FAASNGHAHC VSFLVNFGAN IFALDNDLQT PLDAAASREQ NECVALLDKA
   121  ATAQNIMNPK KVTRLKEQAQ KNARRQIKEC ERLQEKHQNK MAHTYSKEES GTLSSSKGTF
   181  SRSSPSNASA PGTFGSLSKG IKDTFKIKFK KNKDTAEQVG KEGRSGQRNV MEVFREEEED
   241  SFSGDFKEKL QLSAEEDGSV HHESILNRPG LGSIVFRRNR ISSPEDISDS KREFGFKLPS
   301  ELLQRQGASE ADEGAADEEG EENGLKDDLP WDDDEVEWEE DVVDATPLEV FLLSQHLEEF
   361  LPIFKREQID LEALLLCSDE DLQSIQMQLG PRKKVLNAIN RRKQVLQQPG QLVDTSL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ANKS4B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.49
Highest tissue expression: 13 nTPM

Expression across tissuesHPA

Tissue

liver: 13 nTPM
small intestine: 12 nTPM
duodenum: 8.4 nTPM
colon: 8.3 nTPM
rectum: 6.7 nTPM
kidney: 5.5 nTPM

Single-cell type

proximal tubule cells: 41 nCPM
brain excitatory neurons: 4.3 nCPM
brain inhibitory neurons: 1.9 nCPM
podocytes: 1.3 nCPM
distal convoluted tubule cells: 1.2 nCPM
papillary tip epithelial cells: 1.1 nCPM

Immune cell

basophil: 0.2 nTPM
neutrophil: 0.2 nTPM
NK-cell: 0.1 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

cerebellum: 5.8 nTPM
basal ganglia: 2.1 nTPM
cerebral cortex: 2 nTPM
hippocampal formation: 1.8 nTPM
white matter: 1.8 nTPM
pons: 1.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.24
gnomAD pLI: 0
gnomAD missense Z: 0.9
DepMap mean gene effect: 0.21
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ANKS4B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ANKS4B as an antibody target. Whether an autoantibody or antibody against ANKS4B could matter depends on whether native ANKS4B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ANKS4B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ANKS4B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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