CDHR5

Protein identityUniProt · HPA

UniProt accession

Q9HBB8

Gene

CDHR5

Ensembl

ENSG00000099834

Chromosome

11

Canonical length

845 aa

Protein class

Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

This gene is a novel mucin-like gene that is a member of the cadherin superfamily. While encoding nonpolymorphic tandem repeats rich in proline, serine and threonine similar to mucin proteins, the gene also contains sequence encoding calcium-binding motifs found in all cadherins. The role of the hybrid extracellular region and the specific function of this protein have not yet been determined. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jan 2010]

Canonical amino-acid sequenceUniProt

845 residues, UniProt reviewed canonical sequence.

>Q9HBB8|CDHR5
     1  MGSWALLWPP LLFTGLLVRP PGTMAQAQYC SVNKDIFEVE ENTNVTEPLV DIHVPEGQEV
    61  TLGALSTPFA FRIQGNQLFL NVTPDYEEKS LLEAQLLCQS GGTLVTQLRV FVSVLDVNDN
   121  APEFPFKTKE IRVEEDTKVN STVIPETQLQ AEDRDKDDIL FYTLQEMTAG ASDYFSLVSV
   181  NRPALRLDRP LDFYERPNMT FWLLVRDTPG ENVEPSHTAT ATLVLNVVPA DLRPPWFLPC
   241  TFSDGYVCIQ AQYHGAVPTG HILPSPLVLR PGPIYAEDGD RGINQPIIYS IFRGNVNGTF
   301  IIHPDSGNLT VARSVPSPMT FLLLVKGQQA DLARYSVTQV TVEAVAAAGS PPRFPQRLYR
   361  GTVARGAGAG VVVKDAAAPS QPLRIQAQDP EFSDLNSAIT YRITNHSHFR MEGEVVLTTT
   421  TLAQAGAFYA EVEAHNTVTS GTATTVIEIQ VSEQEPPSTD VPPSPEAGGT TGPWTSTTSE
   481  VPRPPEPSQG PSTTSSGGGT GPHPPSGTTL RPPTSSTPGG PPGAENSTSH QPATPGGDTA
   541  QTPKPGTSQP MPPGVGTSTS HQPATPSGGT AQTPEPGTSQ PMPPSMGTST SHQPATPGGG
   601  TAQTPEAGTS QPMPPGMGTS TSHQPTTPGG GTAQTPEPGT SQPMPLSKST PSSGGGPSED
   661  KRFSVVDMAA LGGVLGALLL LALLGLAVLV HKHYGPRLKC CCGKAPEPQP QGFDNQAFLP
   721  DHKANWAPVP SPTHDPKPAE APMPAEPAPP GPASPGGAPE PPAAARAGGS PTAVRSILTK
   781  ERRPEGGYKA VWFGEDIGTE ADVVVLNAPT LDVDGASDSG SGDEGEGAGR GGGPYDAPGG
   841  DDSYI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CDHR5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.51

Highest tissue expression

297 nTPM

Expression across tissuesHPA

ReferencesPubMed · IEDB

Publications for CDHR5 from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.28

gnomAD pLI

0

gnomAD missense Z

-1.2

DepMap mean gene effect

0.01

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• brush border assembly
• cell adhesion
• cell differentiation
• cell-cell adhesion
• homophilic cell adhesion via plasma membrane adhesion molecules
• intermicrovillar adhesion
• regulation of microvillus length

Molecular functions

• beta-catenin binding
• calcium ion binding
• cell adhesion molecule binding

Cellular components

• apical plasma membrane
• brush border membrane
• clathrin-coated pit
• extracellular exosome
• microvillus
• microvillus membrane
• plasma membrane
• synapse

Protein domainsUniProt · Pfam · InterPro

• Cadherin-like
• Cadherin-like superfamily
• Cadherin conserved site
• Protocadherin/Cadherin-related Cell Adhesion

KeywordsUniProt

• Calcium
• Cell membrane
• Cell projection
• Differentiation
• Glycoprotein
• Membrane
• Phosphoprotein
• Repeat
• Signal
• Transmembrane
• Transmembrane helix

InteractionsUniProt · HPA

Protein binding partners of CDHR5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• MYO7B
• USH1C