Seroatlas · Human Serome Atlas

MSL2

E3 ubiquitin-protein ligase MSL2

Also known as: FLJ10546, KIAA1585, msl-2, MSL2_HUMAN, MSL2L1, RNF184

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9HCI7
Gene
MSL2
Ensembl
ENSG00000174579
Chromosome
3
Canonical length
577 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

Enables histone H2B ubiquitin ligase activity. Involved in DNA damage response and protein monoubiquitination. Located in nucleus. Part of MSL complex. Is active in chromatin. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

577 residues, UniProt reviewed canonical sequence.

>Q9HCI7|MSL2
     1  MNPVNATALY ISASRLVLNY DPGDPKAFTE INRLLPYFRQ SLSCCVCGHL LQDPIAPTNS
    61  TCQHYVCKTC KGKKMMMKPS CSWCKDYEQF EENKQLSILV NCYKKLCEYI TQTTLARDII
   121  EAVDCSSDIL ALLNDGSLFC EETEKPSDSS FTLCLTHSPL PSTSEPTTDP QASLSPMSES
   181  TLSIAIGSSV INGLPTYNGL SIDRFGINIP SPEHSNTIDV CNTVDIKTED LSDSLPPVCD
   241  TVATDLCSTG IDICSFSEDI KPGDSLLLSV EEVLRSLETV SNTEVCCPNL QPNLEATVSN
   301  GPFLQLSSQS LSHNVFMSTS PALHGLSCTA ATPKIAKLNR KRSRSESDSE KVQPLPISTI
   361  IRGPTLGASA PVTVKRESKI SLQPIATVPN GGTTPKISKT VLLSTKSMKK SHEHGSKKSH
   421  SKTKPGILKK DKAVKEKIPS HHFMPGSPTK TVYKKPQEKK GCKCGRATQN PSVLTCRGQR
   481  CPCYSNRKAC LDCICRGCQN SYMANGEKKL EAFAVPEKAL EQTRLTLGIN VTSIAVRNAS
   541  TSTSVINVTG SPVTTFLAAS THDDKSLDEA IDMRFDC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MSL2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.57
Highest tissue expression
59 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 59 nTPM
  • thymus: 56 nTPM
  • lymph node: 31 nTPM
  • tonsil: 28 nTPM
  • spleen: 24 nTPM
  • appendix: 18 nTPM

Single-cell type

  • neutrophils: 227 nCPM
  • pdcs: 176 nCPM
  • thymocytes: 175 nCPM
  • neutrophil progenitors: 163 nCPM
  • nk-cells: 156 nCPM
  • myonuclei: 155 nCPM

Immune cell

  • naive CD4 T-cell: 8 nTPM
  • basophil: 6.2 nTPM
  • neutrophil: 5.8 nTPM
  • naive CD8 T-cell: 5.6 nTPM
  • MAIT T-cell: 5.3 nTPM
  • memory CD8 T-cell: 5.2 nTPM

Brain region

  • cerebellum: 51 nTPM
  • white matter: 39 nTPM
  • cerebral cortex: 33 nTPM
  • hypothalamus: 33 nTPM
  • basal ganglia: 32 nTPM
  • midbrain: 32 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about MSL2.

Disease | AllUniProt

Conditions MSL2 is implicated in, by any mechanism.

  • Karayol-Borroto-Haghshenas neurodevelopmental syndrome (KBHS) MIM:620985

Disease | GeneticClinVar

13 pathogenic / likely-pathogenic of 103 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.48
gnomAD pLI
0.62
gnomAD missense Z
2
DepMap mean gene effect
-0.14
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 11% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MSL2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MSL2 as an antibody target. Whether an autoantibody or antibody against MSL2 could matter depends on whether native MSL2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MSL2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MSL2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MSL2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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